I was thinking about it not just because Omicron is more upper-respiratory, but just that mechanical processes are probably not as interesting for research & publication. (Then again hand-washing is an obvious mechanical process that took a long-time to establish and does work.)
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zeynep tufekci Retweeted Kevin Donato
Alright, we have a 2015 review and the answer is maybe yes but don't know. Only 5 randomized studies ever done, apparently. (Found some mild benefit but with so few, hard to tell either way). I always wonder why such common claims don't get trialed more.https://twitter.com/WhatMyWifeYells/status/1476338701823213574 …
zeynep tufekci added,
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zeynep tufekci Retweeted Aartik Sarma
Okay, adding the reviews we do have, and one COVID related preprint coming up.https://twitter.com/AartikSarma/status/1476342990176075776 …
zeynep tufekci added,
Aartik Sarma @AartikSarmaReplying to @zeynepEvidence is limited. Some pediatrics studies found
symptoms (2020) : https://pubmed.ncbi.nlm.nih.gov/32312677/
Evidence is weaker in adults (2015): https://pubmed.ncbi.nlm.nih.gov/25892369/
Pilot study in 2019 found
symptoms,
viral shedding, but larger studies required: https://pubmed.ncbi.nlm.nih.gov/30705369/ 1 reply 2 retweets 66 likesShow this thread -
And here's a preprint. It has a positive finding, but do note it is tiny sample and there is no for-real control group—just comparison to national rates of hospitalization. https://www.medrxiv.org/content/10.1101/2021.08.16.21262044v3 … https://twitter.com/jpdleblanc/status/1476342862405111811 …pic.twitter.com/4lzlnxfvJY
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Okay, here's a 2019 study. Same encouraging findings, same small sample, same "need a bigger trial" recommendation. https://twitter.com/microlabdoc/status/1476346209291886595 …pic.twitter.com/YP39ZOkIiW
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I have the most sincere respect for the power of both placebo and nocebo—aka don't mess with folk medicine—but I can't help but get curious about trials for things with plausibility, like this.
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zeynep tufekci Retweeted Amy Heckathorn
Btw, I asked out of curiosity, and I know this is a common folk-remedy in some cultures but... just in case anyone is encountering this with a practical mindset. DO NOTE THE FOLLOWING. Rinsing nasal passages with tap/contaminated water has real risks!https://twitter.com/heckathorn_amy/status/1476353795927904259 …
zeynep tufekci added,
Amy Heckathorn @heckathorn_amyReplying to @RobbDawson4 @specterm @zeynepYES! Or boiled water. Two people in Louisiana used tap water a few years ago and died from a brain eating amoeba. https://www.cbsnews.com/news/tap-water-in-neti-pots-behind-two-brain-eating-amoeba-deaths-in-2011-investigation-finds/ …15 replies 11 retweets 143 likesShow this thread -
zeynep tufekci Retweeted Dr. Jennifer BLM Glass
Just because I find rigorous testing of folk-remedies interesting… Someone could do a quasi-experiment by using rapid tests like this, but with some folks using rinse/gargle, some not, and also do before/after comparisons (after waiting an hour or so, as per test instructions).https://twitter.com/methanoJen/status/1476276591219064836 …
zeynep tufekci added,
Dr. Jennifer BLM Glass @methanoJenDay 10 of 3x-Pfizer-vaxxed#COVID19 breakthrough case. Still testing faintly +ve. I analyzed all nine of my rapid antigen tests w/ ImageJ & plotted the ratio of the area of sample to the area of control. Saw a linear relationship (R2=0.99) from day 2-10: pic.twitter.com/8vR6r5ygwzShow this thread6 replies 3 retweets 59 likesShow this thread -
By the way, why rigorously test folk-remedies? First: sometimes there’s unintended harm you can uncover only through proper trial. Second: if beneficial, yeay! Third: if no effect found? It seems that the placebo benefit is essentially unshakable, so no harm in finding no effect.
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That one has been repeatedly trialed, no convincing evidence of any benefit. Dexa and fluvoxamine, the other way around.
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Replying to @zeynep
Thanks for your response. Can you explain why this PRINCIPLE trail was paused? The explanation they give (lack of supply) is just not credible. Were subjects having massive adverse effects? Were they getting better?https://bird-group.org/dr-lawrie-requests-interim-results-of-principle-trial/ …
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