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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Ramin Farzaneh-Far MD‏ @rfsquared 15 Dec 2021

      This needs urgent clarification. Assuming 1:1 randomization this suggests ~1/39 16-17 year olds randomized to booster developed myocarditis. We’ve always said clinical trials too small to detect myocarditis but looks like that’s no longer the case with boosters in the young.pic.twitter.com/Yq6tj5tc86

      27 replies 252 retweets 524 likes
    2. zeynep tufekci‏Verified account @zeynep 15 Dec 2021
      Replying to @rfsquared

      You’re giving a public point estimate from a sample of 78? And one incident among the 39? Like how? The confidence interval on that is big enough to string together a few aircraft carriers, and have room to spare.

      17 replies 4 retweets 79 likes
    3. Vinay Prasad, MD MPH  🎙️ 📷‏Verified account @VPrasadMDMPH 15 Dec 2021
      Replying to @zeynep @rfsquared

      you are correct the CI for myocarditis will be massive with this scant info for a healthy 16 yo getting dose 3, but what is the point estimate & CI for their reduction in severe outcomes/ hospitalization reduction from dose 3? i truly don't know

      2 replies 3 retweets 53 likes
    4. zeynep tufekci‏Verified account @zeynep 15 Dec 2021
      Replying to @VPrasadMDMPH @rfsquared

      My question would be if the increase in myocarditis risk from dose one to two is there for from second to third dose—or it just tops out at second, to compare with what the myocarditis risk from breakthrough infection looks like, the relevant comparison, as the first question.

      5 replies 0 retweets 2 likes
      zeynep tufekci‏Verified account @zeynep 15 Dec 2021
      Replying to @zeynep @VPrasadMDMPH @rfsquared

      We already know this group has low severe outcome risk, so not sure there's that much measurable mystery there, but we also know this is an infectious disease and these young people have parents and grandparents. But I don't disagree that this is not a priority booster category.

      9:35 AM - 15 Dec 2021
      • 1 Like
      • NickyTheSquid
      5 replies 0 retweets 1 like
        1. BundlebranchblockMD 👁️ 👁️‏ @Bleedinheart2MD 15 Dec 2021
          Replying to @zeynep @VPrasadMDMPH @rfsquared

          The parents and grandparents can get boosters. We don't increase a child's risk of hospitalization to decrease an adult's!

          0 replies 0 retweets 10 likes
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        2. K00laid‏ @K00laid6 31 Dec 2021
          Replying to @zeynep @VPrasadMDMPH @rfsquared

          With "low severe outcome", do you refer to the severity of the myocarditis? Where tf do you pull that myocarditis can be considered low severe? Are you crazy? Losing "just" 5% of one's heart capacity is ok since when? And do you really think an inflammatory response is a yes/no?

          1 reply 0 retweets 2 likes
        3. Kwanghoon Seok‏ @khoonseok 31 Dec 2021
          Replying to @K00laid6 @zeynep and

          She is from UNC, the origin of Remdesivir, aka the kidney killer. So, myocarditis may not be that serious compared to 50% multiple organ failure among the trial participants.

          0 replies 0 retweets 0 likes
        4. End of conversation

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