See thread, explaining new study: much higher transmissibility for Omicron on top of antibody evasion causing more breakthroughs and re-infections. Do note that even if milder due to immunity and/or lesser intrinsic virulence, still crucial especially for elderly to get boosters.https://twitter.com/mugecevik/status/1471088936999137281 …
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Still more to learn but... Even lots of mild cases all at once with a small portion of severe cases—as we age, the T cell response is less robust, so breakthroughs can progress more readily—can cause a lot of suffering and overwhelm health-care system. Boosters demonstrably help.
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Plus, there are countries that successfully avoided big outbreaks, but are not fully done vaccinating their population let alone boosting due to supply issues. That makes them vulnerable and making sure they can boost especially their vulnerable populations is of utmost urgency.
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zeynep tufekci Retweeted Charre
Don't have time to recap now (maybe there's a thread) but it's been clear even before Omicron, from high-quality randomized trials, that a third dose is really helpful, including against Delta but now against Omicron. Many vaccines are three-dose series.https://twitter.com/atheistsquid/status/1471121959186407430 …
zeynep tufekci added,
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I think a three-dose primary series now, and a booster later preferably with something other than the ancestral spike but with prefusion stabilization, is quite likely where this may land, eventually. I want to emphasize this makes planning and global equity even more important.
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Replying to @zeynep
should elderly/immunocompromised seek their "booster" (4th shot) sooner than 6 mos?
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Check with an actual medical doctor, obviously. If it were me or my loved one, I would start asking around the third month mark tbh given the wave that’s here. Medical doctors can measure antibody response in immunocompromised people, evaluate risk, and advise accordingly.
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Replying to @zeynep @damedacia
Also might be a good idea to stock up on rapid tests. There are increasingly treatments available to help immunocompromise people deal with an infection, which makes early detection important.
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3 mos? 4mos?