Still more to learn but... Even lots of mild cases all at once with a small portion of severe cases—as we age, the T cell response is less robust, so breakthroughs can progress more readily—can cause a lot of suffering and overwhelm health-care system. Boosters demonstrably help.
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Plus, there are countries that successfully avoided big outbreaks, but are not fully done vaccinating their population let alone boosting due to supply issues. That makes them vulnerable and making sure they can boost especially their vulnerable populations is of utmost urgency.
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Don't have time to recap now (maybe there's a thread) but it's been clear even before Omicron, from high-quality randomized trials, that a third dose is really helpful, including against Delta but now against Omicron. Many vaccines are three-dose series.https://twitter.com/atheistsquid/status/1471121959186407430 …
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I think a three-dose primary series now, and a booster later preferably with something other than the ancestral spike but with prefusion stabilization, is quite likely where this may land, eventually. I want to emphasize this makes planning and global equity even more important.
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I'm hearing a lot of reports that, especially for elderly people, negotiating a booster is a problem in many states, with little appointment availability. The bottleneck seems to be logistics and staffing, not supply. At a personal level, check on your loved ones and neighbors!
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You mean a bit like the flu? Maybe. Miraculous isn't it? Five minutes in a pharmacy and you have the upper hand against this virus, and in a better position than humans have ever been against infectious diseases. I'm in awe of such scientific achievements.https://twitter.com/cavallario/status/1471126023400050693 …
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Great thread here on booster studies and existing data.https://twitter.com/Richvn/status/1471134533877743629 …
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A similar trajectory is possible here. UK is experiencing highest recorded number of cases *throughout the whole pandemic*. Rather than arguing over “mildness”, we should take steps now to mitigate the most plausible risks. More is different; faster is different.https://twitter.com/alexselby1770/status/1471154053031899145 …
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This could explain milder disease. However, if virus is replicating in the bronchus, wouldn't virus particles be expected to "seed" the lungs, partly offsetting the effect?
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Are the increased toddler hospitalizations still holding up? Is there any more data on that?
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