People keep assuming almost everyone in the world is seropositive (vaccination or infection). That is just not true: the remaining numbers are still large enough. Plus, as with other diseases, elderly have weaker response plus there is antigenic evolution.https://twitter.com/zeynep/status/1469313745839140866 …
What might it be? The Delta wave in SA had largely receded before Omicron rose, so we did not really get co-circulation. Not sure we have head-to-head comparison of severity in seronegatives yet, either.
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Omicron strain may be less virulent than delta, completely independent of transmissibility. Spreading fast so we won't have to wait long for the data.
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Most interesting question is what cross reactive immunity omicron infection gives against other variants? Although yes, omicron may cause some morbidity, compared with delta it could be akin to a live attenuated vaccine booster for the already vaccinated or infected.
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but symptomatic, a huge wave can still be a strain. If a tiny percent of those are severe that can add up quickly if the wave is big enough. Remember it is in *addition* to other seasonal viruses.