What this data shows is that protecting already vaccinated people from infection is a really bad idea.https://twitter.com/zeynep/status/1468347730133192708 …
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Replying to @TheNickFoy
Wait what you think we should get infected after vaccination so that... we are better protected against infection after vaccination? Given sufficient supply, I'll take the vaccination route.
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Replying to @zeynep
You may want to reconsider based on this data. Also, a post vax infection in a healthy person is likely to be extremely mild.pic.twitter.com/llaDImQSO0
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Replying to @TheNickFoy @zeynep
Also, given sufficient supply, I'd prefer my booster dose go to someone in a lower income country without access who hasn't yet had a first dose. You with me on that,
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Replying to @TheNickFoy
I’ve repeatedly advocated for that. One can hold that to be true without disregarding the obvious evidence that this, like many other vaccines, looks like a 3x dose primary series—should be equitably distributed globally for sure.
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Replying to @zeynep @TheNickFoy
I’ll take you at your word that it’s obvious to you that this looks like a 3x dose primary series. But could you explain to us who don’t find that obvious:
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1) what does that mean (how do we differentiate a 2 dose primary series plus regular boosters from a 3 dose primary series plus regular boosters)? And 2) Why is it obvious?
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Antibody quality and quantity go way up, the third dose goes way beyond "restoring" some waning. This is the pattern wit vaccines we choose to go three doses with. (Not at all uncommon: optimizing a process called affinity maturation).
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Replying to @zeynep @TheNickFoy
It’s nice to get the antibody boost, but the real question in my mind is whether a person is measurably better with or without a booster after 12-24 months. This is especially relevant for my children, who aren’t yet eligible for boosters. Personally, I already got the booster.
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Not great, but not as catastrophic as it could have been. Tested with 2x Pfizer, and shows, yeah, it'll cause a lot of breakthroughs. Those with vaccine *and* infection appeared much more protected: suggests boosters will work well.