We *still* need to wait for epi data to get a better sense of protection against severe disease (expected to remain reasonable and even substantial, but let's see) and vaccine efficacy—lab results do clearly suggest more breakthroughs for sure, but this also needs more epi data.
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Aaand, another lab study on Omicron from
@karolinskainst! Pseudovirus (unlike first), somewhat similar results—same direction. Yes, definitely more breakthroughs and infections, as predicted, but not as catastrophic as it could have been.https://twitter.com/BenjMurrell/status/1468341490632077317 …
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Oh, come on, headline writers. It's been ALMOST TWO YEARS. What she said.https://twitter.com/Boghuma/status/1468357182953562115 …
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One more lab, similar results—though worse than the other two. 2X not enough. Booster helped, but not restored, waned quickly. Previous infection also not enough. (Note all labs are working with small samples & methods vary—epi data will provide clarity).https://twitter.com/CiesekSandra/status/1468465347519041539 …
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Couple of things: more breakthroughs and re-infections are baked in—I think that's long been clear from
@jbloom_lab 's analytic work as well. It's likely milder among the vaccinated/prior infected and the young? Yes, sure but so is every other variant. We still don't know enough.Show this thread -
I'd like, for once, to replace this push and pull between people reassuring us (we don't know enough for that, yet) and catastrophic prophesying with *action*. Unlike early 2020, we have tons of tools we can use to put in place a robust plan of action while we wait for clarity.
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Could it not just be that it's the previous infection that helps those with vaccine and infection? If so this wouldn't give evidence that boosters will help.
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Isn't it the same mechanism? Both infection and vaccine increase antibody count, which increases protection.
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I mean it's pretty bad. Why is everyone in public health convinced that people shouldn't be scared of Covid?
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Not great, but not as catastrophic as it could have been. Tested with 2x Pfizer, and shows, yeah, it'll cause a lot of breakthroughs. Those with vaccine *and* infection appeared much more protected: suggests boosters will work well.