Again: Viruses do not necessarily evolve to be milder—especially if they transmit early, like this one. Our immune system learning about it—via vaccines or infection—can mean better response next time, so milder experience. Not same as virus becoming intrinsically less virulent.https://twitter.com/zeynep/status/1465075561236250631 …
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There’s actually not much data on severity of reinfections and much of the data we have doesn’t suggest a milder course for all. We could just as easily say primary infections are mild on average but the avg isn’t the story. The small % of a large number = many w severe disease.
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Reinfection severity data that suggests many can have a more severe course the second time. And this was all pre-delta and pre-omicron. https://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.clinicalmicrobiologyandinfection.com%2Farticle%2FS1198-743X%2821%2900422-5%2Ffulltext&rc=0& … https://www.cdc.gov/mmwr/volumes/70/wr/mm7008a3.htm?s_cid=mm7008a3_w … https://jim.bmj.com/content/69/6/1253 … https://www.medrxiv.org/content/10.1101/2021.10.04.21264540v1 …
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milder over what course of time? has the data sufficiently accounted for possible years– or life-long impacts? how about viral recombination within a host? the pot'l for the body to house reservoirs of virus? ADE? acute impacts from initially mild cases? degenerative chronicity?
Thanks. Twitter will use this to make your timeline better. UndoUndo
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