Skip to content
  • Home Home Home, current page.
  • Moments Moments Moments, current page.

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @
  • Language: English
    • Bahasa Indonesia
    • Bahasa Melayu
    • Català
    • Čeština
    • Dansk
    • Deutsch
    • English UK
    • Español
    • Filipino
    • Français
    • Hrvatski
    • Italiano
    • Magyar
    • Nederlands
    • Norsk
    • Polski
    • Português
    • Română
    • Slovenčina
    • Suomi
    • Svenska
    • Tiếng Việt
    • Türkçe
    • Ελληνικά
    • Български език
    • Русский
    • Српски
    • Українська мова
    • עִבְרִית
    • العربية
    • فارسی
    • मराठी
    • हिन्दी
    • বাংলা
    • ગુજરાતી
    • தமிழ்
    • ಕನ್ನಡ
    • ภาษาไทย
    • 한국어
    • 日本語
    • 简体中文
    • 繁體中文
  • Have an account? Log in
    Have an account?
    · Forgot password?

    New to Twitter?
    Sign up
zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
Verified account
@zeynep

Tweets

zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

Tweets

  • © 2022 Twitter
  • About
  • Help Center
  • Terms
  • Privacy policy
  • Cookies
  • Ads info
Dismiss
Previous
Next

Go to a person's profile

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @

Promote this Tweet

Block

  • Tweet with a location

    You can add location information to your Tweets, such as your city or precise location, from the web and via third-party applications. You always have the option to delete your Tweet location history. Learn more

    Your lists

    Create a new list


    Under 100 characters, optional

    Privacy

    Copy link to Tweet

    Embed this Tweet

    Embed this Video

    Add this Tweet to your website by copying the code below. Learn more

    Add this video to your website by copying the code below. Learn more

    Hmm, there was a problem reaching the server.

    By embedding Twitter content in your website or app, you are agreeing to the Twitter Developer Agreement and Developer Policy.

    Preview

    Why you're seeing this ad

    Log in to Twitter

    · Forgot password?
    Don't have an account? Sign up »

    Sign up for Twitter

    Not on Twitter? Sign up, tune into the things you care about, and get updates as they happen.

    Sign up
    Have an account? Log in »

    Two-way (sending and receiving) short codes:

    Country Code For customers of
    United States 40404 (any)
    Canada 21212 (any)
    United Kingdom 86444 Vodafone, Orange, 3, O2
    Brazil 40404 Nextel, TIM
    Haiti 40404 Digicel, Voila
    Ireland 51210 Vodafone, O2
    India 53000 Bharti Airtel, Videocon, Reliance
    Indonesia 89887 AXIS, 3, Telkomsel, Indosat, XL Axiata
    Italy 4880804 Wind
    3424486444 Vodafone
    » See SMS short codes for other countries

    Confirmation

     

    Welcome home!

    This timeline is where you’ll spend most of your time, getting instant updates about what matters to you.

    Tweets not working for you?

    Hover over the profile pic and click the Following button to unfollow any account.

    Say a lot with a little

    When you see a Tweet you love, tap the heart — it lets the person who wrote it know you shared the love.

    Spread the word

    The fastest way to share someone else’s Tweet with your followers is with a Retweet. Tap the icon to send it instantly.

    Join the conversation

    Add your thoughts about any Tweet with a Reply. Find a topic you’re passionate about, and jump right in.

    Learn the latest

    Get instant insight into what people are talking about now.

    Get more of what you love

    Follow more accounts to get instant updates about topics you care about.

    Find what's happening

    See the latest conversations about any topic instantly.

    Never miss a Moment

    Catch up instantly on the best stories happening as they unfold.

    1. zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      zeynep tufekci Retweeted Michael Lin, MD PhD  🧬

      Another thread on the risk of sublethal mutagenesis (on the virus, not the human!) from molnupiravir:https://twitter.com/michaelzlin/status/1464424333246447620 …

      zeynep tufekci added,

      Michael Lin, MD PhD  🧬 @michaelzlin
      In conclusion, it would be highly irresponsible to approve molnupiravir unless the possibility of sublethal accelerated viral mutagenesis is thoroughly addressed and satisfactorily rejected, especially within the target population of patients at risk of hospitalization.
      Show this thread
      4 replies 11 retweets 88 likes
      Show this thread
    2. zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      zeynep tufekci Retweeted Chase W. Nelson 倪誠志

      Another, also with a letter in virological. "Mutagenic antivirals: the evolutionary risk of low doses".https://twitter.com/chasewnelson/status/1465219400064122882 …

      zeynep tufekci added,

      Chase W. Nelson 倪誠志 @chasewnelson
      TODAY at #Virological: throughout the #COVID19 pandemic, there has been a tendency to underestimate the potential of #SARSCoV2 to mutate and adapt. As the @US_FDA meets Tuesday to discuss #molnupiravir, @sarperotto and I fear another oversight.🧵 1/15 https://virological.org/t/mutagenic-antivirals-the-evolutionary-risk-of-low-doses/768 …
      Show this thread
      1 reply 5 retweets 72 likes
      Show this thread
    3. zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      zeynep tufekci Retweeted James E.K. Hildreth

      This is Dr. Hildreth on the FDA advisory phrased it after the vote. (He wasn't the only one on the panel to raise the issue).https://twitter.com/JamesEKHildreth/status/1465806607909064705 …

      zeynep tufekci added,

      James E.K. Hildreth @JamesEKHildreth
      FDA AMDAC has voted 13 yes, 10 no for EUA for Merck's molnupiravir COVID-19 drug. I voted no. Inclusive data on mutagenic potential and concerns over generating troublesome SARS-CoV2 variants were not addressed to my satisfaction. Drug has modest 30% reduction in COVID-19 risk.
      2 replies 6 retweets 68 likes
      Show this thread
    4. zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      One question I have is what happen with patience non-compliance? The pill is supposed to be taken over five days, every 12 hours at home (I think 40 pills total). There's going to be a lot of incomplete regimens in this scenario. How does this affect this risk?

      2 replies 10 retweets 163 likes
      Show this thread
    5. zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      (Also, the trial had two phases and the drug had *zero* efficacy in the second phase which is really weird. It suggests regression to the mean so perhaps there is little to no benefit after all. Seems worth a longer study, but that's a separate question).

      3 replies 8 retweets 122 likes
      Show this thread
    6. zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      Overall, we have multiple scientists raising the alarm that a new drug may end up generating new variants, many on the FDA panel voting no citing that very concern, and real questions on whether there's any benefit—already on the low side as claimed. Seems worth taking seriously.

      6 replies 33 retweets 179 likes
      Show this thread
    7. zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      zeynep tufekci Retweeted Sandra

      Pfizer antiviral doesn't use the same mechanism, so does not have the same risk. I think antivirals are an excellent addition to our arsenal. That said, so many on the FDA panel raised this issue, and still little news coverage? How do we get more clarity?https://twitter.com/diagionals/status/1467892862092288000 …

      zeynep tufekci added,

      Sandra @diagionals
      Replying to @zeynep
      Has there been any further information on the pfizer antiviral drug?
      6 replies 20 retweets 143 likes
      Show this thread
    8. zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      Here's a post by @Dereklowe on this question, but also highlighting below the part where he wonders (as have others), if the already low reported benefit is there at all? (The trial data is really weird...) https://www.science.org/content/blog-post/rethinking-molnupiravir …pic.twitter.com/tGTd3jcvdb

      2 replies 10 retweets 70 likes
      Show this thread
    9. zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      zeynep tufekci Retweeted Information Junkie  👨‍💻

      One more thread!https://twitter.com/JustTheFacts37/status/1467890584773963782 …

      zeynep tufekci added,

      Information Junkie  👨‍💻 @JustTheFacts37
      Replying to @zeynep
      Maybe add this one to your list as well? https://twitter.com/lauringlab/status/1467861151983673349?s=21 …
      1 reply 1 retweet 25 likes
      Show this thread
    10. zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      zeynep tufekci Retweeted Derek Lowe

      I think we can assume that there'll be some patient noncompliance (stopping early, skipping doses, erratic timing) as well as re-targeting (hoarded/left-over pills being shared). How does this affect this tail risk—not to the patient, but to society?https://twitter.com/Dereklowe/status/1467906065882927112 …

      zeynep tufekci added,

      Derek LoweVerified account @Dereklowe
      This is an unfortunately good point: will patient noncompliance on Molnupiravir treatment regimes bring on the viral-mutant problems that many have worried about? I haven't been as concerned about that, but this would be the way it could happen. . . https://twitter.com/zeynep/status/1467890223145172996 …
      5 replies 10 retweets 71 likes
      Show this thread
      zeynep tufekci‏Verified account @zeynep 6 Dec 2021

      To some asking: This mechanism doesn't apply to vaccines (vaccines aren't drugs—this is a drug specifically mutagenic to the virus), nor to Pfizer's antiviral (which targets enzymes, and is also not mutagenic to the virus). So concerns are only about this (or similar) drugs.

      11:39 AM - 6 Dec 2021
      • 7 Retweets
      • 57 Likes
      • Gail Nevin James Lewis Giant Foam Dickhat Nanaimo 029 Elizabeth Barile Bethankit Hums Elizabeth Blakeley Graham Webster Dr. Peter Venkman
      7 replies 7 retweets 57 likes
        1. Not Jeff‏ @srsjeff 6 Dec 2021
          Replying to @zeynep

          So why don't we just skip molnupiravir and *just* do the Pfizer drug?

          0 replies 0 retweets 2 likes
          Thanks. Twitter will use this to make your timeline better. Undo
          Undo
        1. Avi Zenilman‏ @avizvizenilman 6 Dec 2021
          Replying to @zeynep

          One running issue is I’m not sure there is a good institutional mechanism or evidence-generating culture within the FDA’s drug or device divisions specific to the population-level risks and benefits of infectious disease treatments and test (vax transmission, rapid tests also)

          0 replies 0 retweets 0 likes
          Thanks. Twitter will use this to make your timeline better. Undo
          Undo
        1. New conversation
        2. Howard Kaplan‏ @savesightMD 6 Dec 2021
          Replying to @zeynep

          Simple question: How would this mechanism compare to 1) immune suppressed patient creation of VOCs 2) incomplete population vaccination 3) Cross-over from animals 4) spontaneous mutations.?This strikes me as theoretical when the virus has so many other significant drivers.

          1 reply 0 retweets 0 likes
        3. Howard Kaplan‏ @savesightMD 6 Dec 2021
          Replying to @savesightMD @zeynep

          The bigger problem is that it does not work particularly well and and has a narrow window of intervention. How many patients will get in to their primary care doc in time to get treated? Likely insurance preauthorization will take the full five days (sarcasm alert).

          0 replies 0 retweets 0 likes
        4. End of conversation
        1. Illegal Emigrant‏ @Illegalemigran1 6 Dec 2021
          Replying to @zeynep

          completing a course of treatment regardless of symptoms typically leads to more resistance than stopping after symptoms resolve.https://www.who.int/news-room/questions-and-answers/item/antimicrobial-resistance-does-stopping-a-course-of-antibiotics-early-lead-to-antibiotic-resistance …

          0 replies 0 retweets 0 likes
          Thanks. Twitter will use this to make your timeline better. Undo
          Undo
        1. New conversation
        2. Pat Mächler  ❎‏ @Valio_ch 19 Dec 2021
          Replying to @zeynep

          Is anyone familiar with psychological research concerning a correct adoption of instructed medication intake schemes among people who are (or who are living in a household with) more doubting of the necessity of a medical intervention?

          1 reply 0 retweets 0 likes
        3. Pat Mächler  ❎‏ @Valio_ch 19 Dec 2021
          Replying to @Valio_ch @zeynep

          Pat Mächler  ❎ Retweeted Pat Mächler  ❎

          https://twitter.com/Valio_ch/status/1472772880127733768 …

          Pat Mächler  ❎ added,

          Fox News GIF by INTO ACT!ON
          Pat Mächler  ❎ @Valio_ch
          My hypothesis is that people who have a sympathy or are close to Covid-19 deniers, who are mostly unvaccinated and who are amongst the groups most likely to get prescription with Molnupiravir, are amongst those groups who will show the worste intake protocol adoptions. pic.twitter.com/zwDXZGV5Ny
          Show this thread
          0 replies 0 retweets 0 likes
        4. End of conversation
        1. New conversation
        2. Stephen St. Onge‏ @Saintonge235 27 Dec 2021
          Replying to @zeynep

          @threadreaderapp unroll please

          1 reply 0 retweets 0 likes
        3. Thread Reader App‏ @threadreaderapp 27 Dec 2021
          Replying to @Saintonge235

          Sorry this content is not available on Thread Reader 😕 It has been removed by the author. 🤖

          0 replies 0 retweets 0 likes
        4. End of conversation

      Loading seems to be taking a while.

      Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.

        Promoted Tweet

        false

        • © 2022 Twitter
        • About
        • Help Center
        • Terms
        • Privacy policy
        • Cookies
        • Ads info