Sharing a few threads on whether molnupiravir (new antiviral on the cusp of approval) risks generating new variants because the mutations it induces may, rarely but possibly, not kill the virus but generate viable variants instead. Many on the FDA panel who voted no raised this.https://twitter.com/CT_Bergstrom/status/1467611446053851145 …
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Replying to @zeynep
Absurdus Retweeted Carl T. Bergstrom
How would you respond to someone who raised this concern about the vaccines themselves?https://twitter.com/CT_Bergstrom/status/1467611467323219979?t=p_H8jWMaosswmO1ZrfA5yQ&s=19 …
Absurdus added,
Carl T. BergstromVerified account @CT_Bergstrom5. Antibiotics, by contrast, can generate negative externalities in the form of antibiotic resistance. If I take an antibiotic, that may increase the chance that antibiotic resistance evolves and that the same drug later fails to work for you.Show this thread1 reply 0 retweets 1 like -
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Replying to @zeynep
Sure, but what would stop them from having selective pressure similar to antibiotics? E.g. selecting for greater transmission? This is not a rhetorical question btw, I'd genuinely like to hear your take on this.
2 replies 0 retweets 0 likes
Yeah, the answer really is vaccines aren't drugs. This question comes up a lot, though, and will look for a longer article on this (or try to get some people to write one). The mechanisms aren't the same with immune system.
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