Sharing a few threads on whether molnupiravir (new antiviral on the cusp of approval) risks generating new variants because the mutations it induces may, rarely but possibly, not kill the virus but generate viable variants instead. Many on the FDA panel who voted no raised this.https://twitter.com/CT_Bergstrom/status/1467611446053851145 …
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To some asking: This mechanism doesn't apply to vaccines (vaccines aren't drugs—this is a drug specifically mutagenic to the virus), nor to Pfizer's antiviral (which targets enzymes, and is also not mutagenic to the virus). So concerns are only about this (or similar) drugs.
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With all the tools we currently have, including the vaccines and Pfizer’s antiviral, it seems really reckless to go ahead w/ these before more study. We really don’t want to rush in and make this thing worse.
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At a science meeting back when Monsanto was revealing "roundup-ready" GMO crops. Ecologists asked equivalent question about evolution of resistance in weeds. Monsanto rep said, "too many mutations required, it won't happen." We knew. 20 years later, resistance is everywhere. 1/2
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20 years of weeds is about 20 generations. For a virus, that's probably a few weeks. 2/2
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Could we please not use the term "noncompliance"? If people aren't taking it, they have a reason for it, and labeling them as noncompliant is judgmental & doesn't focus on solving the problems that are causing pts not to take the med as ordered.
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Thank you for giving a voice to this scary prospect.
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