It's all terrible but... This is legit fascinating for anyone with interest in evolutionary dynamics. Their argument: *On their own*, many Omicron mutations would likely be deleterious, but are adaptive when they *co-occur*... How you get rapid and substantial remodelling...https://twitter.com/alexvespi/status/1467622342251761668 …
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So this means we should mentally prepare for the omnicron+ wave in winter of 2022-2023?
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If you haven’t been following… highly likely that in an immunocompromised host the selection pressure is immense. And under immense selection pressure your get a very atypical ratio of function mutations (“non-synonymous”) over no-functional-change mutations (“synonymous”)https://twitter.com/Clarksterh/status/1467454697078353924 …
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Terrifying if you combine this with Carl Bergson's tweets about Merck's Thor's Hammer treatment possibly inducing sub-lethal mutagenesis. We could go down this evolutionary road on turbo...
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Oops... Carl Bergstrom. Here is the thread:https://twitter.com/CT_Bergstrom/status/1467611446053851145 …
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At least we are giving omicron plenty hosts to test this hypothesis, this is good. Right?? Sigh.
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