Always surprised me that the ‘delayed 2nd dose’ convo got shut down hard and early when we started rolling out vax in 2020. For biological reasons it made sense, but also we had more arms than shots avail so would’ve gotten more protected, faster. Was a smart strategy, ignored.https://twitter.com/michaelmina_lab/status/1467374594063585282 …
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My point here is that the ones calling for doing it without a trial were calling for something that’s a real ethical violation. I’m afraid we are going to take away the lesson here that we should have just rolled this out without testing. I think that’s very, very wrong.
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I think we should have definitely had the trials - as we wrote. That said, we had a lot of data - it showed that at the very minimum efficacy was over 90% after a single dose up through a month. And so at least we knew 1 dose would be highly beneficial for at least 2-3 months.
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I deleted my original reply here because I said something out of line. I was trying to make a point about the no-trials approach and couldn’t fit
@zeynep’s name in the tweet. My regrets on that. -
UK was right to do this"without data". There was no data either way and we killed a lot of people. Although what I didn't understand at the time was that a variant like Delta could change the effectiveness of one dose but not two. But in that way data would have been out of date
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