Agree. I was skeptical in summer—especially since the early data was so confounded. But since then, long before Omicron, we had high-quality data strongly suggesting this is a three-dose primary series. (Happens with many vaccines!). We must equitably vaccinate the world as such.https://twitter.com/priscillagilman/status/1466440935445782530 …
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zeynep tufekci Retweeted Carl T. Bergstrom
I think this is correct. For younger men, there may be an argument against the third shot, though hopefully we will soon get better data on that. (Does the yes very low but real myocarditis risk increase from two to three? Not sure we know yet.)https://twitter.com/CT_Bergstrom/status/1466195783074598912?s=20 …
zeynep tufekci added,
Carl T. BergstromVerified account @CT_BergstromI don't buy it. Many experts may have been hesitant last July — I was. But well before omicron arrived, sufficient evidence was in place to support boosters for all adults (possibly excepting males <29 yrs) and this was pretty broadly accepted by experts. https://www.nytimes.com/2021/12/01/health/covid-omicron-vaccines.html?smid=tw-share … pic.twitter.com/nBPQtxk8kI11 replies 7 retweets 77 likesShow this thread -
zeynep tufekci Retweeted magdalena steinrück
Yes, the third shot isn't just restoring "waning" efficacy, but goes beyond that, and antibodies increase in quality as well as quantity. I will look for a solid article on this (Maybe
@dylanhmorris or@andrew_croxford or someone can write an explainer?)https://twitter.com/m_sciencerocks/status/1466446660368805892 …zeynep tufekci added,
16 replies 74 retweets 263 likesShow this thread -
zeynep tufekci Retweeted Anthony DiPierro
If that is where we end up, this is not at all terrible as an outcome, tbh. Even before the pandemic, I was an avid reader of human history—aka the devastating toll of infectious diseases—and I consider safe and effective vaccines to be wondrous miracles.https://twitter.com/DipierroAnthony/status/1466446586523881475 …
zeynep tufekci added,
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zeynep tufekci Retweeted Where the Tweets have no name
In fairness, the early Israeli data was heavily-confounded. And equity concerns do remain valid. What baffles me is this: There. Have. Since. Been. Highly. Quality. Randomized. Placebo-Controlled. Trials. They were not ambiguous. It's been pretty clear.https://twitter.com/andrewthesmart/status/1466448646455500804 …
zeynep tufekci added,
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zeynep tufekci Retweeted diper911
This is how I feel. We should incorporate lessons from this to better protect against other airborne respiratory diseases, but presenting a booster once a year as some sort of calamity is the ultimate in 21st century problems. Go read some history, folks.https://twitter.com/fKathryn/status/1466449150845886474 …
zeynep tufekci added,
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zeynep tufekci Retweeted John Anderson
Looking at other vaccines, a three-shot primary series (once) and then a (maybe) annual booster (depending on whether a new variant emerges/circulation levels) for adults, and just adding this to childhood series would be my guess.https://twitter.com/truth_campaign/status/1466450587436949517 …
zeynep tufekci added,
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zeynep tufekci Retweeted Ariel Karlinsky
We had randomized, placebo-controlled observer-blind trials on the third shot, that's how.https://twitter.com/ArielKarlinsky/status/1466451738035118082 …
zeynep tufekci added,
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Replying to @zeynep
The truth is, Israeli data was a great first-warning sign for waning VE, but US was high and mighty on "non American data" and failed to notice it. You still didn't say what was confounded in Israeli data, it's not a magic word you know :)
1 reply 0 retweets 0 likes
Oh come on. That early data was, of course, confounded from age to contact patterns to urban/rural to behavior. That doesn't make it useless, but of course people try to tease out confounding. This is how it goes.
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Replying to @zeynep
Israeli MOH also showed age adjusted data. Urban/rural almost completely irrelevant. Results of RCTs which are very similar to Israeli data show that confoundedness was far from major. 1
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Replying to @ArielKarlinsky @zeynep
it's one thing to say "it might be confounded" (as all observational data is) but you and others claimed (erroneously) that it's HEAVILY confounded and useless.
0 replies 0 retweets 4 likes
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