Agree. I was skeptical in summer—especially since the early data was so confounded. But since then, long before Omicron, we had high-quality data strongly suggesting this is a three-dose primary series. (Happens with many vaccines!). We must equitably vaccinate the world as such.https://twitter.com/priscillagilman/status/1466440935445782530 …
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This is how I feel. We should incorporate lessons from this to better protect against other airborne respiratory diseases, but presenting a booster once a year as some sort of calamity is the ultimate in 21st century problems. Go read some history, folks.https://twitter.com/fKathryn/status/1466449150845886474 …
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Looking at other vaccines, a three-shot primary series (once) and then a (maybe) annual booster (depending on whether a new variant emerges/circulation levels) for adults, and just adding this to childhood series would be my guess.https://twitter.com/truth_campaign/status/1466450587436949517 …
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We had randomized, placebo-controlled observer-blind trials on the third shot, that's how.https://twitter.com/ArielKarlinsky/status/1466451738035118082 …
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Yes, and not only because they, too, can get sick and even die—even if much much less so than adults—they can transmit. No child should face the burden of being in a transmission chain to their family. We vaccinate kids against much less deadly diseases.https://twitter.com/MatthewMarchant/status/1466455919848472583 …
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Many. See below from the ACIP meeting. Also, infectious diseases are, well, infectious. Vaccinating children to protect them from the burden of being in the transmission chain that can sicken or even kill their family members is a perfectly good reason. https://twitter.com/Percy43555292/status/1466465048285614091 …pic.twitter.com/jNjTOJnDlJ
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Not just confounded but HEAVILY confounded! In what way? And how is current data NOT confounded?
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Primarily because more weeks since vaccination also meant higher age and higher vulnerability. On top of that, lack of a good unvaccinated comparison group at the same age in countries with very high vaxx rates at high ages.
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Agreed. The messaging around boosters was bungled so badly by well-meaning "thought leaders" that it has increased vaccine hesitancy even among the pro-vaccine people! I have had to talk friends into boosters. Shows you how hard public health messaging is....
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The uncertainty trough. It depends on their role. An excellent analysis
https://rdcu.be/cCuNr pic.twitter.com/TYfFGlS5jn
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Is there any data on 3 dose series vs 2 dose, but separated by much longer interval? I don't fault 2 dose at 3-4 wk interval in beginning, it's a pandemic & we needed high protection v fast. But once emergency is over, any data on 3 dose vs 2 at longer interval?
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