Agree. I was skeptical in summer—especially since the early data was so confounded. But since then, long before Omicron, we had high-quality data strongly suggesting this is a three-dose primary series. (Happens with many vaccines!). We must equitably vaccinate the world as such.https://twitter.com/priscillagilman/status/1466440935445782530 …
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If that is where we end up, this is not at all terrible as an outcome, tbh. Even before the pandemic, I was an avid reader of human history—aka the devastating toll of infectious diseases—and I consider safe and effective vaccines to be wondrous miracles.https://twitter.com/DipierroAnthony/status/1466446586523881475 …
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In fairness, the early Israeli data was heavily-confounded. And equity concerns do remain valid. What baffles me is this: There. Have. Since. Been. Highly. Quality. Randomized. Placebo-Controlled. Trials. They were not ambiguous. It's been pretty clear.https://twitter.com/andrewthesmart/status/1466448646455500804 …
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This is how I feel. We should incorporate lessons from this to better protect against other airborne respiratory diseases, but presenting a booster once a year as some sort of calamity is the ultimate in 21st century problems. Go read some history, folks.https://twitter.com/fKathryn/status/1466449150845886474 …
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Looking at other vaccines, a three-shot primary series (once) and then a (maybe) annual booster (depending on whether a new variant emerges/circulation levels) for adults, and just adding this to childhood series would be my guess.https://twitter.com/truth_campaign/status/1466450587436949517 …
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We had randomized, placebo-controlled observer-blind trials on the third shot, that's how.https://twitter.com/ArielKarlinsky/status/1466451738035118082 …
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Yes, and not only because they, too, can get sick and even die—even if much much less so than adults—they can transmit. No child should face the burden of being in a transmission chain to their family. We vaccinate kids against much less deadly diseases.https://twitter.com/MatthewMarchant/status/1466455919848472583 …
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Many. See below from the ACIP meeting. Also, infectious diseases are, well, infectious. Vaccinating children to protect them from the burden of being in the transmission chain that can sicken or even kill their family members is a perfectly good reason. https://twitter.com/Percy43555292/status/1466465048285614091 …pic.twitter.com/jNjTOJnDlJ
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to what extent is that due to the time delay, rather than the number of doses?
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What about those of us that had J & J early, boosted recently with mRNA, do we need 2 "booster" shots?
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Noob here - Why we think it's primary a third-shot one, not fourth, fifth etc.?
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It could still be a fourth. But we know third is better than 2nd in regards to breadth and quality of antibodies, not just quantity. Polio vax started out as a single shot and then evolved into the 4-dose series we have today as we learned.
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