Folks, absolutely too early to conclude that Omicron is milder or more severe on average, or that vaccine efficacy will be preserved as is, or not—or even why exactly it's spreading. Just too early, and I would not pay any attention to conclusive sounding statements. Needs time.
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That's the only part we have some strong evidence for, from analyzing the genome. But do note: vaccine efficacy measures symptomatic breakthroughs, so it doesn't tell us about their efficacy against severe disease: that, too, will need time.https://twitter.com/damagecase1982/status/1466123483520409608 …
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There's a timeline to the epistemology of this. There are some things we can make reasonable guesses about from the genome and soon-to-arrive lab work, but some key questions need to wait for clinical and epidemiological data. Both
@trvrb &@jbloom_lab had great threads recently.Show this thread -
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Truly appreciate how quickly South African public health officials are sharing data. I’m seeing people conclude from this, though, that Omicron is mild. Maybe. Maybe not. Still too early. Only thing that seems assured is more breakthroughs and re-infections. Still need time.https://twitter.com/MRCza/status/1467138777881747456 …
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Disease progression takes time, serostatus of many is not always known, age cohorts have different contact patterns, founder effects are a thing, society isn’t mixed homogeneously… Need time to disentangle. I do hope it’s mild but let’s not talk ourselves into conclusions, yet.
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And there’s also the risk of long covid, even (and possibly especially) with mild/asymptomatic infection
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"Mild" infections are by definition cases that don't need hospital treatment (oxygen). As health systems are stressed to save lives, comprehensive understanding of what happens after those "mild" infections (long covid/cf, etc.) is neglected in health policies.
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