This is so stupid. Annual boosters would be no big deal. That said, many other vaccines are a three-dose primary series. Some then have finite number of boosters—one or two, sometimes years later. The pandemic brought many hardships. Oh-noes-a-three-dose-primary-series isn't one.https://twitter.com/day_diff/status/1460979166816395276 …
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zeynep tufekci Retweeted zeynep tufekci
Here's the deal. The "booster" is turning out to be more than a boost for waning efficacy. It's both true that we should prioritize this globally—health-care workers and high-risk people everywhere first—and that it's a no-brainer at the individual level.https://twitter.com/zeynep/status/1460976854811262984 …
zeynep tufekci added,
zeynep tufekciVerified account @zeynepReplying to @Atul_GawandeIndeed.@dylanhmorris keeps pointing out the third shot improves antibody quality, not just quantity, and the efficacy doesn't just get "restored" to before, it sometimes exceeds anything seen before. And there are many other vaccines with three-dose primary series.16 replies 61 retweets 276 likesShow this thread -
zeynep tufekci Retweeted Santa Monica
I'm very sympathetic to the notion that we haven't been where we need to be with communication around many issues. But adjusting dosing schedule once data comes in from large-scale real-life implementation is routine. It's called Phase IV trials.https://twitter.com/SantaMonicaBorn/status/1460984114853474306 …
zeynep tufekci added,
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zeynep tufekci Retweeted Chise 🧬 🧫 🦠 💉
Yep. A lot of childhood vaccines are three-dose primary series. Some have a few boosters, but most of them do not need annual ones. We don't yet know where this one will end up, but this seems like the least of our problems.https://twitter.com/sailorrooscout/status/1460985569668915200 …
zeynep tufekci added,
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Brian Wasik Retweeted Andrew L. Croxford
'every 6mo' just doesn't comport with what we know about immunity. The immune response to each dose isn't likely to be linear in both effect and decay. Especially in absence of sig antigenic change. Andrew made a nice little graphic to explain.https://twitter.com/andrew_croxford/status/1435914603364560899?t=4CKXRs46wofGRCssWULvUA&s=19 …
Brian Wasik added,
Andrew L. Croxford @andrew_croxfordReplying to @AlistairHaimes @PaulNukiIt likely will but the fading will not be always directly proportional to the previous dose. The intervals (orange) between fading protection may get longer, thus reducing need for ‘actual’ boosters on an annual basis. I’ve used felt-tips for Alistair.
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A key problem is that people keep thinking of vaccines/immunity as if they were drugs—like, say, antibiotics. You see this in discussions of side effects and safety, and now this. I have to say, some of the stupidity of the debate around dose-sparing strategies did not help this.
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