I could only tune in between meetings so feel like I must have missed something. My understanding is that Kurilla would have recommended a single dose to kids with prior infection (at least given current seroprevalence vs. trends in hospitalization incidence).
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Replying to @pickettjessica @MichaelTeng88
Yes but that’s straight up not operationalizable.
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Also he’s simultaneously unconvinced that immunobridging data support efficacy and also wants to do fewer doses of the vaccine he doesn’t think works.
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Replying to @ENirenberg @pickettjessica
I'm baffled. The immunobridging data, combined with the efficacy analysis, are pretty clearly supportive. Fewer doses of a 10ug vaccine would work better?
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Replying to @MichaelTeng88 @pickettjessica
I think his thinking is the disease in kids is not big deal, 1 dose as insurance might block against the rare hospitalizations and likely avoids myocarditis risk. IMO- 1 dose isn’t durable enough for… anything and pediatric COVID is about much more than just hospitalizations.
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It’s not even his weirdest position. His continual complaint about vaccines being directed agains the Wuhan virus strain instead of Delta is tiresome when they show efficacy against both, but this time launched into a tirade implying that it would be negative for a future strain.
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The future variant that is all but guaranteed to be a sublineage of the variant we know the vaccine protects against that doesn’t exist yet means we should reformulate the vaccine to cover against the nonexistent variant it probably already covers. Brilliant.
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Somebody needs to explain pre-fusion S as an immunogen to him.
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@McLellan_Lab
I’m totally kidding but I’m so grateful for your and your collaborators’ work on structural optimizarion of vaccine immunogens1 reply 0 retweets 7 likes -
Replying to @ENirenberg @MichaelTeng88 and
Thanks Edward. Just happy to contribute to these vaccines.
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Thank you so much for your work!
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