Nejm this week
Act 1: review of “target trial” framework for observational studies by @_MiguelHernan
https://www.nejm.org/doi/full/10.1056/NEJMp2113319?query=featured_home …pic.twitter.com/MasDIT4umY
Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org
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Nejm this week
Act 1: review of “target trial” framework for observational studies by @_MiguelHernan
https://www.nejm.org/doi/full/10.1056/NEJMp2113319?query=featured_home …pic.twitter.com/MasDIT4umY
Act 2: study from qatar claiming Pfizer vaccine effectiveness reduced to 20% after month 4, regardless of variant https://www.nejm.org/doi/full/10.1056/NEJMoa2114114?query=featured_home …pic.twitter.com/qaq1DVktQz
Act 3: zero discussion of huge discrepancy with the “target trial,” which has already been conducted. https://www.medrxiv.org/content/10.1101/2021.07.28.21261159v1.full.pdf+html …pic.twitter.com/jT9TxFBWV2
One thing that occurs to me frequently lately is that despite all the discussion of waning immunity, the epi curve still looks pretty much like what you’d expect from ongoing improvement in population immunitypic.twitter.com/9sWcsRLHHn
Polls are vaporware, kinda, elections are data. With all due respect to all the other work, the epi curve is data. 
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