Everyone's immunity to #covid19 will wane over time after 1st infection. Then their chances of being hospitalized go up rather than down on subsequent infections, if the data in this paper hold up to subsequent studies. Do you disagree with that statement? Thank you for engaging.
As for Delta, agree! I said in tweet you replied that Delta made things worse. No doubt. I know the Lancet paper: it is yet an estimate, and not for vaccination. With clinical outcomes, the test is in the pudding. Are there hospitals full of re-infected? That would be alarming.
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The virus is circulating in multiple countries. People who have been infected and/or vaccinated are getting exposed and some re-infected/breakthroughs. Re-infections getting more severe would result in a wave worse than anything before: unvaccinated plus more severe re-infected.
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I don't think that reinfection in general will be likely more severe. It depends of too many parameters (inhaled infectious dose, neutralizing antibodies and memory B cells). I believe it is too soon to tell either way but that we should worry about long term sequelae of Covid.
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