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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Flo Débarre‏ @flodebarre 30 Sep 2021

      WB: infections of 4 and 4 ferrets with viruses w/ and w/o FCS; transmission of the virus w/; mutant w/o did not transmit -> FCS enhances replication in airway and favours airborne transmission (may also be involved in anosmia symptom)

      1 reply 1 retweet 1 like
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    2. Flo Débarre‏ @flodebarre 30 Sep 2021

      WB: work published herehttps://www.nature.com/articles/s41564-021-00908-w …

      1 reply 1 retweet 1 like
      Show this thread
    3. Flo Débarre‏ @flodebarre 30 Sep 2021

      WB: member of G2P-UK virology consortium, collaborating to assess consequences of genetic variation in SARS-CoV-2https://www.ukri.org/news/national-consortium-to-study-threats-of-new-sars-cov-2-variants/ …

      1 reply 0 retweets 1 like
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    4. Flo Débarre‏ @flodebarre 30 Sep 2021

      WB: P681H mutation confers optimized S1/S2 cleavage, contributes to the enhanced fitness of Alpha variant in human airway cells (shown through reverse genetics system)

      1 reply 1 retweet 2 likes
      Show this thread
    5. Flo Débarre‏ @flodebarre 30 Sep 2021

      WB: P681R mutation in Delta confers even more optimized S1/S2 cleavage In vivo: Syrian golden hamster model to see if the cell-based experiments translate to actual in vivo effects // to compare transmission of alpha/delta variants Shorter exposure time did not discriminate

      2 replies 3 retweets 2 likes
      Show this thread
    6. Flo Débarre‏ @flodebarre 30 Sep 2021

      WB: measuring infectious virus emitted to the air by the hamster. Hamsters infected with Delta emit more infectious virus to the air than those infected by Alpha (at least a detectable difference between the variants)

      1 reply 1 retweet 3 likes
      Show this thread
    7. Flo Débarre‏ @flodebarre 30 Sep 2021

      WB: P681R mutation does not confer a fitness advantage to Alpha Probably the other mutations in the spike (away from the FCS) affect the FCS (e.g. stabilize spike) and may explain result

      1 reply 3 retweets 4 likes
      Show this thread
    8. Flo Débarre‏ @flodebarre 30 Sep 2021

      WB: Concluding teaser: first-in-the-world SARS-CoV-2 Human infection study completed at Imperial College; Delta challenge planned

      2 replies 2 retweets 4 likes
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    9. zeynep tufekci‏Verified account @zeynep 30 Sep 2021
      Replying to @flodebarre

      She doesn't have a preprint out on this talk, I presume? The hamster/delta one?

      1 reply 0 retweets 0 likes
    10. Flo Débarre‏ @flodebarre 30 Sep 2021
      Replying to @zeynep

      I tried to post the refs when I saw them, and did not see one for this last part (and since I have a chance: thanks for the awesome work you do and great tweeting!)

      1 reply 0 retweets 2 likes
      zeynep tufekci‏Verified account @zeynep 30 Sep 2021
      Replying to @flodebarre

      Thank you for tweeting the talks!

      6:25 AM - 30 Sep 2021
      • 1 Like
      • Federico Gueli
      1 reply 0 retweets 1 like
        1. Flo Débarre‏ @flodebarre 30 Sep 2021
          Replying to @zeynep

          So there's indeed no preprint yet, because the results are very recent

          0 replies 0 retweets 0 likes
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