Btw: we followed up on that story with the cryo EM structure of HKU1 HE (Hurdiss, Nat. Com. 2020).
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ooh thank you this is *exactly* what i was looking for!
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Replying to @wanderer_jasnah @raouljdegroot and
May I ask if you know why OC43's mutation rate is so low (3-4 times lower than SARS-CoV-2) ?
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Replying to @babarlelephant @wanderer_jasnah and
I would guess the error frequencies of OC43 and SARS-CoV-2 RdRp are in the same ball park. It may reflect differences in conditions acting on a virus that emerged very recently and is still expanding in a new host population and another one long-established, wide-spread, endemic.
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Replying to @raouljdegroot @babarlelephant and
I would guess that rates at which mutations are fixed in expanding lineages of a new virus are quite different from that in a omnipresent, well-adapted, 'optimized' one.
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Replying to @raouljdegroot @babarlelephant and
I agree with this assessment.
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Replying to @jbloom_lab @raouljdegroot and
This is worrying for the confidence in dating of the common ancestor between SARS-CoV-2 and bat viruses.
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Replying to @babarlelephant @jbloom_lab and
Molecular clock estimates should be regarded with caution. As for OC43, I've been on the hunt for historical samples for precisely this reason. All US/UK 1960's isolates seem to have been lost except for the ATCC and (perhaps) "Kunkel" strains. Ideas anyone?
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Replying to @raouljdegroot @wanderer_jasnah and
Maybe try asking around some of the classical CoV labs to see what's in their freezer? Not OC43, but I know Susan Weiss still has the SD/SK isolates. I don't think anybody has published on them since the 80s or 90s.
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Replying to @renegadenarwhal @wanderer_jasnah and
I am with one of those classical labs.
We all threw out so many valuable samples cleaning up fridges, freeing up space.
I did contact members and 'heirs' of the Common Cold Unit and people from the CDC but in vain. So far no luck securing the elusive "Kunkel" strain either.1 reply 0 retweets 1 like
Eeek. But that makes me hopeful someone somewhere has forgotten something that will turn out to be useful.
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