Do people know that the 1890 pandemic was likely caused by another coronavirus, OC43 (that was then novel?) Nowadays, no longer novel, it is one of the causes of the common cold. We're obviously not living in the OC43 pandemic since, and we won't live in a COVID pandemic forever.
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Replying to @zeynep
The 1890/91 'Russian flu' having 'likely' been caused by HCoV-OC43 may be a bit too strong s statement. It is not implausible that the 1890/91 'Russian flu' was caused by one of the current endemic coronaviruses, though OC43 may not be the best candidate. 1/
5 replies 15 retweets 131 likes -
Replying to @BallouxFrancois @zeynep
HCoV-NL63 may actually be a more plausible candidate for the 1890/91 pandemic for a a series of reasons, including: - NL63 uses the same ACE2 host cell receptor, which leads to fairly systemic infections - NL63 is a bit more virulent than OC43 2/
3 replies 8 retweets 70 likes -
Replying to @BallouxFrancois @zeynep
- When we estimate the time to the 'Most Recent Common Ancestor' using all HCoV genomes available, we get a date largely compatible with a late 19th century host jump into humans for NL63, whereas it is more recent for OC43. 3/ Credit: Charlotte Jenner and
@LucyvanDorppic.twitter.com/r7HAyvggI9
5 replies 5 retweets 65 likes
Fascinating thank you. (I'd seen a paper with a different jump date estimate for NL63). I do hope you find that lung tissue! (The obvious point I was trying to make was that there is no reason to think SARS-CoV-2 would stand outside all biology and history).
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