It's of course not this simple. The biological mechanism isn't the same, but the process of evolution shares many commonalities. So while it's wrong to say "antibiotic resistance evolves easily so vaccine evasion will" it's also wrong to say that nothing we learn translates.https://twitter.com/zeynep/status/1436312862713126913 …
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Replying to @yarbsalocin @zeynep
To me the key difference isn't that the immune response is polyclonal, but there's heterogeneity of antibody response across a population. It's like those arguments in CS that show that random algorithms are less susceptible to adversarial attack than any deterministic ones
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I'm with Baym on this, its selective pressure. what is different about selective pressure?
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I wouldn't say I have a side here
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gotcha. I am an evolutionary immunologist, or I was. ;). and I thought about this question and couldn't come up with "what is different." maybe I dont understand what is being conflated. perhaps not the basic mechanism, but what is being selected against?
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There is a common assertion/belief that by vaccinating during a time of transmission, we are making "vaccine resistant" variants *more* likely. The argument is a jumble of antibiotic analogies, and random pickings from population genetics and within-host processes.
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by during "time of transmission" you mean, giving a vaccine injection while a person is concomitantly being infected? I guess I have not read this theory. id theorize that, if during the time of viral contraction, the airways and lungs, etc are being exposed. 1/2
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No, time of transmission in the population. Essentially, lucky you if you are not, I'm constantly getting asked if we are doomed to a forever pandemic because we are vaccinating while the virus is circulating, and we won't reach 100% vaccination (or some version thereof).
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1/2 this paper: Using well-established principles of population genetics and evolutionary ecology, we argue that two key differences between vaccines and drugs explain why vaccines have so far proved more robust against evolution than drugs. First, vaccines tend
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