It's of course not this simple. The biological mechanism isn't the same, but the process of evolution shares many commonalities. So while it's wrong to say "antibiotic resistance evolves easily so vaccine evasion will" it's also wrong to say that nothing we learn translates.https://twitter.com/zeynep/status/1436312862713126913 …
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To me the key difference isn't that the immune response is polyclonal, but there's heterogeneity of antibody response across a population. It's like those arguments in CS that show that random algorithms are less susceptible to adversarial attack than any deterministic ones
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Viruses do evade vaccines. Common cold. HIV. Flu. Etc.
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Look also at the polyvalence of the immune response. Analagous to the use of multi-drug cocktails in infectious disease and cancer. One drug is often readily evaded. Cocktails of three, much less often.
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