When India decided to prioritize 1st doses of COVISHIELD & space doses by 3 months, there was a lot of controversy. It was absolutely the right move. 1) more 1st doses = more lives saved 2) longer gap = better immune response 3) leverages hybrid immunity (infection+1 dose)
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Replying to @swapneilparikh
The question was whether it was based on scientific evidence or due to vaccine shortage.
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Replying to @KalidasuGirid
The more important questions are: 1) did it save lives 2) does it result in a better immune response 3) is it the right move in a country with high seropositivity 1) yes, saves lives 2) yes, induces better immunity 3) yes, leverages high seropositivity
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Replying to @swapneilparikh @KalidasuGirid
One was clear from all the models back last winter. (Hence UK and Canada did what they did). The weird part is a lot of people said two and three could well happen—based on immunology—but it got lost in the “how dare you deviate from trials” faux outrage.
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Replying to @zeynep @KalidasuGirid
Full disclosure, initially I did think it was risky to deviate from trials. However, I found the NYT piece that you & Dr Mina co-authored very compelling. It changed my mind (along with modeling & data on immune responses w/ different intervals. Fwiw y’all were clearly right.
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Now that it’s clear that first dose prioritization saves lives and leads to a better immune response, some in India have shifted goal posts to “that doesn’t matter, the govt. did it because of supply”. Yeah, no shit geniuses. It saved lives & also resulted in a superior response.
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Similar accusations against UK’s JVCI. Despite how clear it was that it was a reasonable choice—even with remaining uncertainty. One of the biggest misses of the pandemic that we didn’t consider this globally. Maybe AZ (supply) then mRNA (great heterologous response) globally.
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