UK JVCI: “There is very good immunological and vaccine effectiveness evidence that the longer you leave that second dose the better for Pfizer and eight weeks seems to be a reasonable compromise.” US did three weeks. CDC said six weeks okay but I know people asked & got refused.https://twitter.com/HugoGye/status/1417051348336529409 …
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Another topic on which clarity would be good. (The three week interval is strikingly short for *any* vaccine. I know of a single other vaccine that even *allows* an interval as short as three weeks. It seems Pfizer picked three weeks to speed up trials, but then it got stuck).
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Replying to @zeynep
I've yet to see the evidence on differences in asymptomatic breakthroughs. The immune data is nAb titer that may be larger boost with greater interval. But again - absolute threshold of protection is not something we can easily measure. And the tradeoff was time.
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Replying to @BrianRWasik
I'm just annoyed that we don't set up trials for these things. We're administering hundreds of millions of doses in a hurry, why not randomize a bit among some less risky sub-population? UK Recovery seems to be the only proper effort, tbh, to measure the kitchen sink phase.
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Replying to @zeynep
I hear you. I contain multitudes. I want more trial data but resources but hindsight. Hundreds of successes and failures. Glad you continue to catalog it. Shame if we fail to learn and improve.
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Yeah. I get wanting to get through the trials fast, makes sense! But it's a pandemic, so let's get going on the phase IV stuff ASAP as well. Fraction of the wasted resources (and worse, confusion) from not having a trial imo. Also how many lives did dexa save? UK Recovery ftw.
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