UK JVCI: “There is very good immunological and vaccine effectiveness evidence that the longer you leave that second dose the better for Pfizer and eight weeks seems to be a reasonable compromise.” US did three weeks. CDC said six weeks okay but I know people asked & got refused.https://twitter.com/HugoGye/status/1417051348336529409 …
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I think UK's Recovery trial was exemplary, and I just wish we had more, both randomized and cohort studies. There's a bunch of things around which we don't have the clarity we easily could have had. (FWIW: this isn't saying any answer is wrong. I just want more trials).
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No, hard to get answers that way, different places and time periods. Again: trials, cohort studies, registries etc. doing (as best as we can) apples-to-apples comparisons is what we needed. Would have been really smart and cost-effective in the long run.https://twitter.com/LakePatina/status/1417166352717127682 …
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Makes sense. Though "know" seems elusive with evolving virus.
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Israel did 3 weeks w Pfizer and the UK did 8 weeks. However both countries' VE data have been very similar for Pfizer so far.
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Would same apply for AstraZeneca?
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Just focusing on one variable in multiple trade-offs problem seems to me a wrong approach…is the benefit from waiting longer outweighed by other risks?
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Everyone is quoting someone else. The fact is there is no data. After so many public health communication botch-up (mask, origin etc.), this type of no-data backing-up publication with mass audience only sows confusion and is irresponsible.
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We can certainly wait until this fall, compare case study data between US (3~4 weeks interval) and Canada (Longer) before making any conclusion.
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