Really important to note this. There may be the usual fears around B.1.617 because people will see a paper with "x-fold reduction in neutralizing antibodies" etc. Keep in mind that drop DOES NOT correspond even to reduced efficacy, let alone ability to prevent severe cases.https://twitter.com/VincentRK/status/1391869808858238979 …
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Yes indeed shame there was no trial! But from the UK and Canada's 'trials' it looks like a strong pfizer option v most variants for healthly <60s. Beyond that, more caution needed, not clear just how far you can delay the dose past 6-8 weeks currently either.
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In the UK they pushed out the time to the second jab up to 12 weeks, because of a surge in cases at the time. Currently about 30% of the population have only had one jab (peaked at ~50% I think) (see: https://coronavirus.data.gov.uk/details/vaccinations …). I'm no expert, but seems to have been successfulpic.twitter.com/MyRtlDRhV4
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Also backed up to some extent by study data on AZ vaccine with at least Neut. Antibodies better if longer gap.pic.twitter.com/PIGKRqRb85
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Trial in uk includes 28d vs 12wk - https://www.nihr.ac.uk/news/worlds-first-covid-19-vaccine-alternating-dose-study-launches-in-uk/26773 …
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Agree! B.1.351 has much higher fold escape (like ~30x) from vaccine and convalescent antibodies/ patient sera compared to B.1.617.2 but adenovirus vectored & mRNA vaccines still give EXCELLENT protection against severe clinical disease, hospitalization and death.
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Would some of you folks please write this out in a readable format?
I do my best to keep explaining but there is non-stop fear-mongering and intentional/unintentional panic over the "x-fold reduction" papers.. Most not even getting the NAb point correctly, let alone T cell etc. - Show replies
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thanks for sharing this! You have been a voice of reason in this pandemic. I am also really curious to hear what you know about post-Covid antibodies vs vaccine-induced antibodies?
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