Fascinating preprint (H/T @zeynep ) - in host diversity is quite limited (i.e. variants aren't emerging from typical infections spreading)
This really brings up the concept of making sure our immunocompromised patients are followed up appropriately, and vaccines are pushedhttps://twitter.com/KATarinambraun/status/1388312255222124544 …
-
-
Replying to @zchagla
Also, from what I can tell, in many countries, convalescent plasma is still used broadly and without a lot of checks/controls. I checked with a few doctors I know elsewhere and they did not know of this issue:https://www.nature.com/articles/s41586-021-03291-y …
1 reply 3 retweets 5 likes -
Replying to @zeynep
Yes - much of our messaging for india (despite everything) has been stop using plasma. Even the indiscriminate use of monoclonal antibodies may lead to big trouble - and these patients likely need specialized care and followup.https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciab392/6261427#.YI0_pHm4AQo.twitter …
1 reply 1 retweet 2 likes -
Replying to @zchagla
What's the best guideline for this I can forward to doctors etc. in other countries? (not India) Ideally, WHO but accessible ones from other countries could work too. Especially during surges (Turkey has one now), all of that can get fairly indiscriminate in practice.
1 reply 0 retweets 1 like -
Replying to @zeynep
we put together this document in http://indiacovidsos.org with
@paimadhu@KrutikaKuppalli for just pragmatic care at home and eliminating therapies that don't work. There is also a great evidence review at https://www.covid19treatmentguidelines.nih.gov/whats-new/ including plasma.1 reply 2 retweets 4 likes -
WHO guidance is here: https://www.bmj.com/content/370/bmj.m3379 … They're a bit behind on some therapies (tociluzimab, plasma) but from what I hear it's coming soon!
@Bram_Rochwerg2 replies 0 retweets 2 likes -
IL-6 receptor blockers coming next! Soon!
1 reply 0 retweets 3 likes -
Replying to @Bram_Rochwerg @zeynep and
@Bram_Rochwerg what about plasma? Given there is multiple negative studies AND the potential for harm - should there be a statement out for this? (happy to help as well!)2 replies 0 retweets 0 likes
It would be really helpful. Plasma is being used indiscriminately in many places. (I cannot measure how often, obviously, but I know it's happening and awareness of this downside seems to be little to none).
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.
We deep seq’d
carefully at long-term infxs.
1/12