Fascinating preprint (H/T @zeynep ) - in host diversity is quite limited (i.e. variants aren't emerging from typical infections spreading)
This really brings up the concept of making sure our immunocompromised patients are followed up appropriately, and vaccines are pushedhttps://twitter.com/KATarinambraun/status/1388312255222124544 …
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Yes - much of our messaging for india (despite everything) has been stop using plasma. Even the indiscriminate use of monoclonal antibodies may lead to big trouble - and these patients likely need specialized care and followup.https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciab392/6261427#.YI0_pHm4AQo.twitter …
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What's the best guideline for this I can forward to doctors etc. in other countries? (not India) Ideally, WHO but accessible ones from other countries could work too. Especially during surges (Turkey has one now), all of that can get fairly indiscriminate in practice.
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My article: Looking at transmission across individuals/family clusters, the virus doesn't change much, suggesting variants aren'tthe result of typical infections - but more chronic infections in immune compromised.
@zeynep posted a case in an individual who exemplified that
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We deep seq’d
carefully at long-term infxs.
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