The man who leads the UK RECOVERY trials which produced incredibly useful information—including drugs that greatly reduce mortality—suggests a randomized trial of delayed dosing. Amazing how “controversies” evolve.
(Yes, we obviously should, as per first tweet in this thread.)https://twitter.com/MartinLandray/status/1353272270270181379 …
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The infection rates are confounded but why wouldn’t measuring antibody titers be sufficient evidence? Are they also confounded somehow?
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You’d need to know correlation between antibody titers and real world protection which is still unknown afaik. We don’t use antibody titers to approve vaccines we need an actual trial.
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Real world data looks amazing actually even accounting for worst case confounding bias. And we’re not suggesting one dose only, just delaying second doses for some people by a few weeks - so low risk just because of short time frame.
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UK now has a trial going including arms comparing Pfizer and AZ at 4 vs. 12 weeks (They are calling these controls - headline 'treatment' arms mix the two vaccine types)https://www.gov.uk/government/news/world-first-covid-19-alternating-dose-vaccine-study-launches-in-uk …
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