Biden administration will indeed stop keeping second dose in reserve and front-load the vaccine distribution. (NB: I advocated for a *trial* asap on delayed booster & not keeping second dose in reserve. I also support having these trades-off discussions).https://www.cnn.com/2021/01/08/politics/biden-vaccine-strategy/index.html …
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Do we still need a trial or can we study UK recipients now up to 12 weeks with one dose?
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Are they doing 12 weeks delay with *both* Pfizer and AstraZeneca? I thought the 12 weeks delay was only with AZ.
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Yes rescheduling is a pain. We can do it without rescheduling and that means extra doses come in 3 weeks. Trial intervals chosen to optimize other parameters so certainly not ideal from a policy and resource scarcity perspective. If the CDC has pre-okayed 6 weeks...
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Delaying now and resuming later assumes that will have built up a higher daily capacity at a later date to be able to vaccinate the second doses because you will be building a backlog.... how guaranteed is that capacity and are we willing to delay further than 6 weeks ?
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And I think the 6 week interval was allowed by CDC since some trial participants had that interval. So if trial didn’t exclude them, inside info for vaccine companies suggests it can’t be too far from optimal, right?
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Canada is delaying the 2nd dose by 16 weeks for Moderna, Pfizer and Astrazeneca.
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Worse, health care officials are telling people like my 80-yr-old mother that the vaccine is 90% effective 3 weeks after just one dose.
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I think you should be able to "donate" your second shot appointment to anyone you want.
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(Yes, we obviously should, as per first tweet in this thread.)