Also see this thread by one of the country's leading virologists on why she thinks we should delay the boosters in order to increase early coverage. (Disclosure: the article she's linking to about the risks of increased transmissibility is mine)https://twitter.com/VirusesImmunity/status/1345086669607890945 …
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We have been running the trial in the UK though, if you seperate out the lockdown effect (dramatic across all ages) the results aren't so good!
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I’d be interested to see the data to back this up if you have it at hand thx
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Use the U.K. Pfizer rollout as the evidence?
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I think that is why she italicised trial. A frustrated dog at the fact that the U.K. is one big control group so we can’t compare efficacy against NOT spacing doses. A commitment to gold standards in an emergency is in itself a risk though.
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Canada is doing this, but control group is tricky because it’s only health care workers who are getting a second dose, at least in Ontario. This might be where data across the provinces with different approaches provides a natural experiment.
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Yes we’ve done it in almost 100% of cases. It seems to have paid off although making the decision and then generating data to support it is never my preferred strategy...
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Shouldn’t we also target the states/cities with more vaccines if there is a surge starting there?
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There shouldn’t even *need* to be a trial for this in a pandemic. You delay dose 2 but give 10s of thousands of ppl (eg HCWs) a set of rapid tests. If surveillance shows unexpected waning of protection, that’ll show quickly and you put ppl back at the head of the line for jab 2.
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Requiring a gold standard of evidence is an unaffordable luxury in an emergency. If there’s a sound immunological explanation for protection lasting, at least for 2-3 months, do the delay, and change course if it turns out to be wrong. [Tho, looks like it’s not wrong]
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(Yes, we obviously should, as per first tweet in this thread.)