Yesterday morning:
great results from large trial of AZ‘s #covid19 vaccine
Yesterday evening:
DSMB „expressed concern that AstraZeneca may have included outdated information from that trial, which may have provided an incomplete view of the efficacy data“https://www.nih.gov/news-events/news-releases/niaid-statement-astrazeneca-vaccine …
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This whole pandemic is a rollercoaster I would like to get off, but AstraZeneca sure look like they are intent on sending us through a few extra loops and dips while we‘re on it...
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AstraZeneca have issued a statement on the DSMB’s concerns now incl. this beautiful example of clear crisis communication: "We have reviewed the preliminary assessment of the primary analysis and the results were consistent with the interim analysis."pic.twitter.com/GIEfIbSNJ3
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As far as I can parse this: Results yesterday were interim analysis based on data with cut-off point February 17. More up to date data is coming in form of the primary analysis within 48 hours and should not look all that different… Let’s wait and see…https://www.astrazeneca.com/media-centre/press-releases/2021/update-following-statement-by-niaid-on-azd1222-us-phase-iii-trial-data.html …
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Tony Fauci talking about this now on
@GMA: DSMB "wrote a rather harsh note to them and with a copy to me saying that in fact they felt that the data that was in the press release, were somewhat outdated and might in fact be misleading a bit, and wanted them to straighten it out."2 replies 19 retweets 136 likesShow this thread -
Fauci: “It really is unfortunate that this happened. You know this is really what you call an unforced error, because the fact is, this is very likely a very good vaccine and this kind of thing does as you say do nothing, but really cast some doubt about the vaccines …"
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“It was not necessary”, says Fauci. "If you look at it, the data really are quite good. But when they put it into the press release it wasn't completely accurate.”https://www.goodmorningamerica.com/news/video/fauci-discusses-concerns-oxfordastrazeneca-vaccine-data-76626319 …
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zeynep tufekci Retweeted zeynep tufekci
AZ needs to change their name to "unforced error" or "own goal". Yesterday, I decided to wait to talk about the announcement till we got a paper or more details (just in case you know, because it's... them). I had been thinking maybe I'm too uncharitable.https://twitter.com/zeynep/status/1374060809144438785 …
zeynep tufekci added,
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Whatever they are doing, the victim is confidence in the vaccine.
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