The AZ doses sitting in our warehouses are not approved for US now (trial not over)& won't be before we get the supply for everyone from approved ones. They don't help you, but there are places that have approved them that face transmissible variants now.https://twitter.com/MichaelDavSmith/status/1372165033698992135 …
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Many places face B117, a terrible variant against which these vaccines show little/no loss of efficacy. BUT CRUCIALLY LOSS OF EFFICACY AGAINST MILD/MODERATE DISEASE DOESN'T MEAN "NO PROTECTION." Immune system is not a seawall that just gets washed over. https://twitter.com/peteyreplies/status/1372166204606009344 …
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How is this remotely defensible "ANTIFA" secretary? We are sitting on doses we will never use. The manufacturing is here, going well and has three separate sources. People are dying right now. Plus, transmissible variants need *early* intervention. Now.https://twitter.com/MKMaybe/status/1372168083977158660 …
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I hear the people saying "why can't I get an appointment now." These vaccines gathering dust don't help because US trial isn't even concluded and it will not be approved before every eligible American is already offered an appointment. It won't help us. Let it do some good.
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Already made! By NYT reporting, we have 30 to 60 million doses of a vaccine that will not be approved in time to help the US supply languishing in Ohio and Baltimore. On top of that, there are pre-orders of excess hundreds millions—but that's separate.https://twitter.com/BarryCPearson/status/1372167156570406921 …
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I know it's hard to imagine this, after months of shortages. But the numbers are there. US overbooked vaccines—we didn't know which would work. Now we do. The supply of approved ones made *here* will soon exceed our population. Let's let go of ones that won't be approved in time.
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Also, for people asking. The variants are part of the argument for why we should vaccinate globally, as fast as possible, but key reason is because they cause enormous suffering now, and exponential threats are best countered early. From my newsletter: https://zeynep.substack.com/p/ill-take-the-hippie-dippy-wishful …pic.twitter.com/UBhqofozFy
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Let me repeat. These vaccines in our warehouses are not approved for the United States. They will not be approved in time. Dude in my mentions who thinks I should feel stupid because they're used in Georgia? You live in Atlanta, Georgia. They are approved in Georgia, the country.pic.twitter.com/e1CDTXjJOc
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Yep. They have been manufactured. They cannot be used here. US trial isn't over, let alone approval. They are approved in 140+ countries through a global initiative. We also have 100+ million Novavax (all excess) in the pipeline that won't make it in time. https://twitter.com/david1watson/status/1372171700469706752 …
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It is a jarring shift from shortages but it is reality. Just Pfizer & Moderna are on track for 600 million doses by July. J&J supply is 10+ million per month. We have 100 million Novavax in the pipeline. US only has 260 million vaccine eligible people. https://twitter.com/Valentine721/status/1372184003063726087 …
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Remember how upset we got when we hard a few doses here and there were being wasted? US has at least thirty, likely about sixty million, *already manufactured* doses of vaccines that cannot be used here (no approval) and will NOT be approved in time. We can send them out today.
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Most likely holdup here is the political perception. The administration doesn't want to be seen as sending vaccines while shortages are working their way through. But we can do the math here—these won't be approved in time—and give political support to the smart and humane path.
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Yes, of course. Soon enough we will be discussing giving away more of our excess because our pipeline truly exceeds our population likely by hundreds of millions. But, we can do that next month. These are doses needed NOW that we cannot and will not use.https://twitter.com/josh_wingrove/status/1372187510248509452 …
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Look, the US will release these vaccines we clearly won't use—eventually. They won't be approved in time here. The only question is timing. My point is we should do it NOW, especially with more transmissible variants spreading. A vaccine today is worth more than one in a month.
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To folks saying AZ is an inferior vaccine so we shouldn't give it away even if we can't use it. "Not approved yet because US trial not concluded" doesn't mean inferior. Novavax looks spectacular (from trials elsewhere) but also not approved here because trial not concluded...+
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... but it's definitely true that AZ rollout has been a spectacular mess, but that's separate. (I will probably rant on that in my newsletter). So far 11 million doses in UK, ~6 in Europe, 500,000 in Canada have been administered... It's not a vaccine just for poor/brown folk.
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We can figure out the politics of where AZ should go. There are countries with large outbreaks (especially of that terrible B117 variant) in Europe, for example. Other countries elsewhere may ask for them, solving the "optics" issue. What's on us is to demand they get used, now.
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Because it's not endangering anyone. It's approved in the UK, Canada, EU and through the WHO coalition, in 140+ countries and has been given to 17 million people in UK and EU. The US FDA requires the trials it requires, and that's a different discussion.https://twitter.com/4030lisa/status/1372230955973410816 …
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I don't have a strong opinion on where they go—there are many choices, but yes, whatever is going on in EU is an issue. However, as you can see below, Canada—facing a potential B117 surge in many locations—has approved them, would use them, and needs them.https://twitter.com/chadcrichton/status/1372239202293780480 …
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Folks, we have ~60 million doses *sitting* in our warehouses in Ohio and Baltimore for vaccines that aren't approved here, whose US trials haven't concluded, that will not be approved till too late. They are approved in Canada and her mom needs one now.https://twitter.com/tanjamaier17/status/1372243923209441283 …
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I know, it's hard to mentally adjust: last few months have been dominated by the dire, ongoing shortages. It's hard to believe. But the math is clear: we will have more the enough vaccines for anyone who wants one here in the US sooner than AZ would be approved here in the US.
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I get this, and there is certainly a problem with whatever European countries think they are doing (I can't make sense of it) and the way AstraZeneca was rolled out was suboptimal. But that's a different problem—not a reason to let vaccines go to waste.https://twitter.com/cschneider8224/status/1372245248374579201 …
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Yes, there are multiple ways to ship those doses gathering dust out now, even with some guarantees for replacement (we won't need! we really will not need!) for if and when they are finally approved here and there is some (I can't imagine how) urgent need.https://twitter.com/ariehkovler/status/1372254589332946944 …
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Another option. Just give it to Covax—the global initiative to vaccinate the world—and let them handle the rest. We don't have to figure out all the optics; we just have to commit to immediately letting go of doses we can't use that can do good elsewhere.https://twitter.com/NavinPokala/status/1372279931770667017 …
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Not so burdensome, but it'd be awesome if the "how dare you propose to dump an inferior vaccine elsewhere" people could directly duke it out with the "yes we have enough and those aren't approved but what if we ever need those great vaccines here?" folk.
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The number of people who claim it's bad to call for releasing vaccines approved by large number of countries around the world and have been administered *checks notes* mostly to people in UK, Canada & Europe is amazing.https://twitter.com/DannyAlberta77/status/1372567922497908739 …
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Yes, folks, we're all aware some European countries have paused for a day to investigate reports of clots and AZ vaccine. If they find anything negative, of course the vaccine will be suspended everywhere. Otherwise, it will continue being administered in Europe, UK and Canada.
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And two great updates! European Medical Agency's Safety Committee studying AZ clotting reports says they "found no evidence of a quality or a batch issue”, says to continue vaccination. And US starts to release our stockpiles (that we will not get to use!)https://twitter.com/jeffmason1/status/1372576853341442051 …
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Thrilled to hear that US is releasing (can't otherwise be used) vaccines to Canada & Mexico. We must do *everything* we need to do to increase the supply. Nobody, anywhere, should have to wait until 2022 to be offered a safe and effective vaccine against COVID-19. We can do this.
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Release them! Yeay! There is more AZ in a Baltimore facility, too, I believe, and we should produce as many vaccines as we possibly can including other ones (J&J is using Merck facilities to produce more here!). Everyone who wants a vaccine should get one in 2021. It’s possible.https://twitter.com/noahweiland/status/1372643037403357194 …
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