I wrote about how need for statistical power affects vaccine trial endpoints, what that means for "vaccine efficacy"—and why our layperson mental model of the immune system should *not* be a sea wall keeping the waves out, and getting overrun by tall ones.https://zeynep.substack.com/p/vaccine-efficacy-statistical-power …
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Great article. I've lost count of how many times I've tried to explain protective vs sterilizing immunity, clinical trial design, partial immune evasion, etc. Now I can just point people at your excellent article.
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