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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Natalie E. Dean, PhD‏Verified account @nataliexdean 25 Feb 2021

      Puzzling a bit over J&J's endpoints for severe/critical disease (reported 85%) and hospitalization (reported 100% after 28 days). It's hard for me to understand why these would be so different, given the definition of severe/critical disease. Thoughts from the Twitterverse?pic.twitter.com/YXeK4588Ym

      9 replies 24 retweets 129 likes
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    2. Natalie E. Dean, PhD‏Verified account @nataliexdean 25 Feb 2021

      In simpler terms, who are the 8 PCR confirmed vaccinated individuals with severe/critical disease, and why were they not hospitalized? Maybe I'm missing some pertinent info. (Definition of severe/critical disease below.)pic.twitter.com/rGkrbqCM4M

      11 replies 3 retweets 51 likes
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    3. zeynep tufekci‏Verified account @zeynep 25 Feb 2021
      Replying to @nataliexdean

      In Pfizer trial, the one "severe" case was SpO2 of 93%—she got no medical intervention. Same definition seems to apply here; so if that was the only indicator for severe for some, it would not correlate with hospitalization. (But I wish trials had standardized definitions!)

      1 reply 0 retweets 14 likes
    4. Aaron Richterman, MD‏ @AaronRichterman 25 Feb 2021
      Replying to @zeynep @nataliexdean

      yes, the only thing on that list that would not result in hospitalization is mild hypoxia. Someone with Covid in the ED and 92% o2 that otherwise looks well probably not going to be admitted

      2 replies 0 retweets 8 likes
    5. zeynep tufekci‏Verified account @zeynep 25 Feb 2021
      Replying to @AaronRichterman @nataliexdean

      Yeah. Cases are few enough here that I think not a big deal, but definitely real value if we had better standardization of definitions and more non-aggregated data with its time distribution to better understand a few anomalies like this.

      2 replies 1 retweet 3 likes
    6. Natalie E. Dean, PhD‏Verified account @nataliexdean 25 Feb 2021
      Replying to @zeynep @AaronRichterman

      Yes, I think there are a few layers. Both the definition (in terms of symptoms), but then also the timing (7, 14 or 28 days after vaccine), centrally confirmed versus any PCR confirmed, based on MRU form or post hoc analysis of any hospitalization. So lots of analyses to parse.

      1 reply 0 retweets 1 like
      zeynep tufekci‏Verified account @zeynep 25 Feb 2021
      Replying to @nataliexdean @AaronRichterman

      Yes, all noted. We're kind of getting away with these partly because the results are as strong as they are and the differences seem to converge fairly well (like with the centrally versus PCR-confirmed). But we'd be in trouble if it were more borderline, wider discrepancies...

      9:49 AM - 25 Feb 2021
      • 4 Likes
      • Elaine G Roby Bhattacharyya Dr Ed
      1 reply 0 retweets 4 likes
        1. Aaron Richterman, MD‏ @AaronRichterman 25 Feb 2021
          Replying to @zeynep @nataliexdean

          Some will be cleared up by the final analysis I’m sure (eg still waiting on 70% serology data) but yes more details on the severe cases would be helpful (even if its pretty clear what characteristics would have to be based on their definition)

          0 replies 0 retweets 0 likes
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