5. Based on this, I think the possibility that these vaccines don't meaningfully reduce transmission (to the point that populations can move back towards normal life in due course) is low enough that we should treat this as a mostly theoretical concern at this point.
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Aaron Richterman, MD Retweeted Aaron Richterman, MD
6. An enduring lesson of this pandemic (& others) is the need to communicate uncertainty honestly (in both directions). Of course its reasonable to be careful, but lets not forget that this theoretical concern is being cited as a reason not to get the vaxhttps://twitter.com/AaronRichterman/status/1348494121019826178?s=20 …
Aaron Richterman, MD added,
Aaron Richterman, MD @AaronRichtermanReturning to normal activities is one important motivator for public to get vaccinated. Emphasizing that vaccines are unlikely to facilitate this because lots of transmission might happen anyway undermines this, especially when that seems unlikely based on what we know now
https://twitter.com/MonicaGandhi9/status/1347988651179798530 …Show this thread2 replies 6 retweets 31 likesShow this thread -
Aaron Richterman, MD Retweeted Eric Meyerowitz, MD
7. implications of monoclonal post-exposure prophylaxis data on transmissionhttps://twitter.com/EricMeyerowitz/status/1354231883190722571?s=20 …
Aaron Richterman, MD added,
Eric Meyerowitz, MD @EricMeyerowitz1/ Key question right now is how much SARS-CoV-2 vaccines will decrease transmission. Data from Regeneron mAb cocktail prevention press release may help us think about this https://investor.regeneron.com/news-releases/news-release-details/regeneron-reports-positive-interim-data-regen-covtm-antibody …Show this thread1 reply 0 retweets 7 likesShow this thread -
Aaron Richterman, MD Retweeted Aaron Richterman, MD
8. More on why reducing symptoms/severity w vaccines will probably reduce transmissionhttps://twitter.com/AaronRichterman/status/1351548094710652928?s=20 …
Aaron Richterman, MD added,
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8a. (Aside - Good paper with biases to be mindful of when comparing secondary attack rates of symptom/asymptomatic in households (page 19). h/t
@mugecevik) https://dash.harvard.edu/handle/1/37366192 …pic.twitter.com/ez5IssUk0F
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Aaron Richterman, MD Retweeted Aaron Richterman, MD
9. Some more discussion on Moderna dose 2 testinghttps://twitter.com/AaronRichterman/status/1350591945702318083 …
Aaron Richterman, MD added,
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Aaron Richterman, MD Retweeted
10. Implications from regular pcr monitoring after natural infection. Less infections, lower viral load, more asymptomatic. Will reduce transmission. https://twitter.com/dylanhmorris/status/1357003968208121861 …
Aaron Richterman, MD added,
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Aaron Richterman, MD Retweeted Aaron Richterman, MD
10a. That said, similar caveats as below re whether those were even all reinfections.https://twitter.com/AaronRichterman/status/1355567294882131972 …
Aaron Richterman, MD added,
Aaron Richterman, MD @AaronRichtermanImportant thread below on immunologic basis for skepticism of 0% protection by prior natural infection on reinfection with B1.351 suggested by the small novavax study in S Africa So why else might they have found identical cases by sero+/-? Speculation before seeing full data: https://twitter.com/profshanecrotty/status/1355552010158764036 …Show this thread1 reply 0 retweets 5 likesShow this thread -
11. More data from the Oxford/az randomized clinical trial. Vaccinated ppl who developed infection had lower viral loads and were pcr+ for one week shorter time relative to placebo. True for both asymptomatic and symptomatic cases. =>reduced transmission https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3779160 …pic.twitter.com/NsnUzCmrZk
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Aaron Richterman, MD Retweeted Yaniv Erlich
12a. And real world data from Israel. Interesting analysis inferring vaccine status by age and following cycle thresholds over time, suggesting lower VL in vaccinees w infection. Cool time series. Caveat: unclear what symptom status is but assume mostly symptom prompted testing.https://twitter.com/erlichya/status/1358477762495930368 …
Aaron Richterman, MD added,
Yaniv Erlich @erlichyaIdea
: we know the age of the person and the date of the test. Since vaccination was started with 60+, we can compare the average Ct value positives in this age group as a function of time and compare to 40-60 as a control. Here are the results:
[Red: 60+;Blue:40-60] pic.twitter.com/X24YG5SCmZShow this thread2 replies 1 retweet 5 likesShow this thread
zeynep tufekci Retweeted Roy Kishony
Similar Ct comparison (preprint not out yet).https://twitter.com/RoyKishony/status/1358695273468469250 …
zeynep tufekci added,
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Replying to @zeynep @AaronRichterman
Is this the preprint?https://www.medrxiv.org/content/10.1101/2021.02.06.21251283v1 …
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