So, immunologically speaking, I don't disagree. But if we are going to change the recommendation (1 dose, delayed 2nd, etc)-then we are going to have a lot of ppl who mistrust us even more. We've asked ppl to follow the science/evidence. We've asked ppl to trust us (scientists)..
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Replying to @jabarocas @michaelmina_lab and
While we think that the vaccine will be effective w/delayed dose, there's no hard evidence. We're swimming upstream against a river of mistrust already. For those of us on the ground, having the conversations, this is a hard sell. IMO.
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Replying to @jabarocas @michaelmina_lab and
On the first, Michael and I had asked for a trial of delaying the dose back in December partially because I am indeed very attuned to the question of trust. Even though delaying doses is not uncommon, even a request to collect data was treated as a no-go. So a few things on that.
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Replying to @zeynep @jabarocas and
Insisting that the only scientific way was whatever the initial trial happened to be—which isn't a practice set in stone, is modified routinely for other vaccines, and given the emergency we face, def something to discuss—kind of became an own-goal, I think. So now it's harder. +
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Replying to @zeynep @jabarocas and
Meanwhile, both WHO and CDC have said six weeks is okay but we can't even do that, partly because of that unnecessarily rigid messaging. We could have had better data, we don't. UK could have had a more targeted approach, they don't.
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Replying to @zeynep @jabarocas and
If one had two children, and these vaccines and a shortage, is the answer to vaccinate only one, prime & booster three weeks apart, and leave the other completely unvaccinated, or vaccinate both if they get the booster six weeks later? We wanted data because that is our question.
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Replying to @zeynep @michaelmina_lab and
And we squandered a prime opportunity to answer that and now are left making best guesstimates and asking ppl to trust us (when many of those ppl we’ve (med establishment) f-Ed over in the past too many times to count.
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Replying to @jabarocas @zeynep and
This has been a cathartic rant session to have with you
@zeynep. Always appreciate your perspective and learn a lot!1 reply 0 retweets 2 likes -
Replying to @jabarocas @michaelmina_lab and
Thank you, same. I'm also worried about the mistaken impression we gave on transmission (many now falsely believe no effect), and got people thinking variants make vaccines completely ineffective. Hearing real hesitancy around both. That said, I'm hopeful because of reality!
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Replying to @zeynep @jabarocas and
Yes, the convergent evolution is worrisome and we're gonna eventually need boosters but all the vaccines look excellent on all the measures that count, and now we know even with the worse variants! I think as people see the real results, the vaccines will make their own case.
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Just got to cover as many people as possible as fast as possible. The results will speak. I think we hit a home run with vaccination—that wasn't foretold—and people don't realize that 60% was kind of a *ceiling* with flu... Tunnel still kinda grim but I feel better about end now.
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