More adding support for delayed 2nd dose strategy. @mtosterholm + @mlipsitch are supportive. Early calls to consider this (notably op-ed by @michaelmina_lab + @zeynep in mid-Dec) were too quickly dismissed by some, IMO.
It's a race against new variants.https://www.cidrap.umn.edu/news-perspective/2021/02/experts-tout-delaying-2nd-covid-vaccine-dose-us-deaths-mount …
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Very low risk. The immune system isn’t going to drop off a cliff at 28 days. Nor at 45 or 60 days.
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Right. What I'm hearing—and would like some clarity and data on—is that the Pfizer three week interval is mostly an artifact of trying to speed up trials and may be too short for the best response (even if there were no shortage). Dunno. Anyway WHO/CDC both say six weeks okay.
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Agreed, it would have been good if they added factorial sub trials of 4-8 weeks delay for the 2nd dose to see how it compared to 3. Factorial trials aren’t that much harder to do, but many don’t want to write complex protocols thinking it might scare FDA.
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Yes. I think they wanted quick results and shortening interval between the doses does that. But if they had thought ahead about the shortages (easily anticipated) they could have done a factorial design varying the interval between doses.
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J&J two-dose trial is 57 days between, I believe
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