LOL. Just as a bunch of other studies said, and as many doctors and patients testified.https://www.northjersey.com/story/news/coronavirus/2021/01/27/nj-covid-hydroxychloroquine-can-help-some-patients/4247506001/ …
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Replying to @michaelbd @GPIngersoll
This study wasn’t randomized or blinded
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Replying to @jbarro @GPIngersoll
And it was small. The Ford study was large, though not double blind.
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We have more than enough randomized HCQ studies. Too many. No effect so fat. It’s hard to imagine this many studies missing an effect. But I believe there’s even more ongoing. No reason to look ever at non-randomized at this stage.
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Anyway “no reason to ever look at non-RCT studies” after some are done is an absurdity and it’s not how medicine is practiced.
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That’s not what I said. There have already been many many many RCT studies for this. So after that, no, you don’t need to look at the non-randomized ones. If you had none, you would look at them and think they might be suggestive. But we’re way past that point.
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You missed what I said. Observational studies are usedby physicians all the time even when available RCTs contradict them. Because physicians face novel circumstances or surprising results and need all knowledge that’s on hand
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Replying to @michaelbd @zeynep and
And even then RCTs usually only produce a certain confidence level. My father in law, is one of these rare people who has “paradoxical” reactions to certain psych drugs. Following RCTs nearly killed him two years ago.
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That’s fine. It’s just you wouldn’t look at an observational study for efficacy for a drug that has been studied so many times with randomized studies—as this article did. People do look at *observations* for subgroups, it’s done all the time. Usually RCTs help define them too.
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