Vaccines offer AMAZING protection from COVID-19. But if you do get sick, do they protect you from severe illness? At first glance, yes: ZERO hospitalizations for COVID in trial pts who got vaccine. But, so few even got sick; how sure can we be? On closer look: also YES… 1/3https://twitter.com/roby_bhatt/status/1355146062684688388 …
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Yes, and similar quirk may explain discordance between 85% efficacy vs severe for j&j (already great) and complete protection from hosp/death (even better)https://twitter.com/MonicaGandhi9/status/1355957317045420032 …
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I’m already seeing “which vaccine should you choose” articles that belie these important points, plus compare efficacy from trials in different time periods/variants/sample sizes. Let’s get some vaccines out there!!! What is this talk of choice etc. etc.?
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The vaccine severe case in the vaccine group also had someone with under 93% oxygen saturation and didn't need medical care. One definition of severe for vaccine group and different one for placebo?
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Nope, same definition - the FDA one. May seem counterintuitive, b/c "severe" doesn't always line up with hospitalization; it's defined by vital signs.https://twitter.com/roby_bhatt/status/1355176490489446402 …
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