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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Roby Bhattacharyya‏ @roby_bhatt 31 Jan 2021

      Roby Bhattacharyya Retweeted Roby Bhattacharyya

      Vaccines offer AMAZING protection from COVID-19. But if you do get sick, do they protect you from severe illness? At first glance, yes: ZERO hospitalizations for COVID in trial pts who got vaccine. But, so few even got sick; how sure can we be? On closer look: also YES… 1/3https://twitter.com/roby_bhatt/status/1355146062684688388 …

      Roby Bhattacharyya added,

      Roby Bhattacharyya @roby_bhatt
      As far as I can tell, nobody in a trial who received a dose of any COVID vaccine (Pfizer/BNT, Moderna, Novavax, J&J) has been hospitalized for COVID. Some "severe disease" in a few, but defined by O2 sat, not needing admission. https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial …
      5 replies 56 retweets 148 likes
      Show this thread
      zeynep tufekci‏Verified account @zeynep 31 Jan 2021
      Replying to @roby_bhatt @AaronRichterman

      The single Pfizer “severe” case is a person with 93% oxygen saturation who didn’t need medical care—let alone hospitalization. Eagerly hoping we get standardized definition and details for J&J so we can communicate this. Already heard people ask whether to bother with J&J. Aargh!

      11:13 AM - 31 Jan 2021
      • 5 Retweets
      • 45 Likes
      • did everything right discocat J Polar Sophia Grene Lili S. Dr Kevin Purcell 🇬🇧🇮🇪🇺🇸 😷💉💉💉 Lené Colbert MAB2017 Marika Muller
      3 replies 5 retweets 45 likes
        1. New conversation
        2. Aaron Richterman, MD‏ @AaronRichterman 31 Jan 2021
          Replying to @zeynep @roby_bhatt

          Aaron Richterman, MD Retweeted Monica Gandhi MD, MPH

          Yes, and similar quirk may explain discordance between 85% efficacy vs severe for j&j (already great) and complete protection from hosp/death (even better)https://twitter.com/MonicaGandhi9/status/1355957317045420032 …

          Aaron Richterman, MD added,

          Monica Gandhi MD, MPHVerified account @MonicaGandhi9
          Replying to @AaronRichterman @RidleyDM
          Yes, the fact that so many of those are hospital criterion (admission to the ICU means admission to the hospital) means to me that most of the severe managed outside the hospital met that criteria due to O2 sat <93% but not too sick. So, even more hopeful that J&J very effective.
          1 reply 1 retweet 10 likes
        3. zeynep tufekci‏Verified account @zeynep 31 Jan 2021
          Replying to @AaronRichterman @roby_bhatt

          I’m already seeing “which vaccine should you choose” articles that belie these important points, plus compare efficacy from trials in different time periods/variants/sample sizes. Let’s get some vaccines out there!!! What is this talk of choice etc. etc.?

          1 reply 1 retweet 8 likes
        4. Show replies
        1. New conversation
        2. NK Leb‏ @NickytaLeb 31 Jan 2021
          Replying to @zeynep @roby_bhatt @AaronRichterman

          The vaccine severe case in the vaccine group also had someone with under 93% oxygen saturation and didn't need medical care. One definition of severe for vaccine group and different one for placebo?

          1 reply 0 retweets 1 like
        3. Roby Bhattacharyya‏ @roby_bhatt 31 Jan 2021
          Replying to @NickytaLeb @zeynep @AaronRichterman

          Roby Bhattacharyya Retweeted Roby Bhattacharyya

          Nope, same definition - the FDA one. May seem counterintuitive, b/c "severe" doesn't always line up with hospitalization; it's defined by vital signs.https://twitter.com/roby_bhatt/status/1355176490489446402 …

          Roby Bhattacharyya added,

          Roby Bhattacharyya @roby_bhatt
          Replying to @roby_bhatt @EricTopol @HelenBranswell
          Confirmed, J&J trial (https://clinicaltrials.gov/ct2/show/NCT04505722 …) uses FDA definitions of severe disease (p 13 of https://www.fda.gov/media/137926/download …): SpO2 ≤ 93% on room air, HR > 125 bpm, RR > 30/min, or P/F < 300. Seems like the SpO2 is most likely to be relevant in outpatients.
          1 reply 0 retweets 1 like
        4. Show replies

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