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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 26 Jan 2021
      Replying to @BiellaColeman @lisang

      Why is Merck (vaccine failure in early stage from a late entry which is common in vaccine development) and Moderna (excellent news from an amazing vaccine, plus they say already planning for future) a "one-two punch"? It's tiny bad news (Merck not big player) plus GREAT news.

      3 replies 0 retweets 5 likes
    2. Lisa Goldman‏Verified account @lisang 26 Jan 2021
      Replying to @zeynep @BiellaColeman

      I like your interpretation and hope you are right. Right now I am seeing overwhelmed doctors talking about an incoming tsunami, a vaccine that is resistant to a new and more contagious strain, AND no evidence that the government(s) have a mass vaccination plan to implement.

      1 reply 0 retweets 1 like
    3. Josh Nathan-Kazis‏Verified account @joshnathankazis 26 Jan 2021
      Replying to @lisang @zeynep @BiellaColeman

      I suppose "grim" is a matter of perspective, but I do think the Merck news is pretty bad - they have an extraordinary record of developing vaccines, and at least one of their Covid-19 vaccines was based on an established platform, which has significant advantages.

      1 reply 0 retweets 3 likes
    4. Josh Nathan-Kazis‏Verified account @joshnathankazis 26 Jan 2021
      Replying to @joshnathankazis @lisang and

      And on the Moderna news - of course it's reassuring that they still expect the vaccine to protect against the S.A. strain. But they were worried enough make a new booster! My sense, in interviews two weeks ago, was that Pfizer, at least, didn't expect to be at this point so soon.

      1 reply 0 retweets 1 like
    5. Josh Nathan-Kazis‏Verified account @joshnathankazis 26 Jan 2021
      Replying to @joshnathankazis @lisang and

      I don't mean to downplay the successes so far at all. And I respect your work a lot, and appreciate the pushback. But in the context of all the rollout troubles so far, those two updates yesterday morning seemed quite negative to me.

      1 reply 0 retweets 1 like
    6. zeynep tufekci‏Verified account @zeynep 26 Jan 2021
      Replying to @joshnathankazis @lisang @BiellaColeman

      zeynep tufekci Retweeted Eric Topol

      The Merck news is a disappointment for sure, but a minor hiccup since they are a late entry (though of course, would have been better) but the Moderna news was *excellent*. This is what the last day looked like to me, a lot of good news:https://twitter.com/EricTopol/status/1354129134134288384 …

      zeynep tufekci added,

      Eric TopolVerified account @EricTopol
      Summary of good pandemic news👍 1. Pivotal trial of early monoclonal antibodies reduces death & hospitalization (big, this is a 1st) 2. Vaccination & mitigation works to contain B.1.1.7 (as shown by Israel) 3. The other 501Y.V2/3 variants are unlikely to reduce vaccine efficacy
      2 replies 0 retweets 6 likes
    7. zeynep tufekci‏Verified account @zeynep 26 Jan 2021
      Replying to @zeynep @joshnathankazis and

      It was one of the least grim news days in a while! Now if J&J crashes and burns, I'll be very, very disappointed. But having excellent vaccines shown to continue to be effective, Merck already looking ahead... I find it positive and not at all grim. That was my objection.

      1 reply 0 retweets 5 likes
    8. zeynep tufekci‏Verified account @zeynep 26 Jan 2021
      Replying to @zeynep @joshnathankazis and

      (Sorry Moderna looking ahead not Merck. Moderna looking ahead with a booster is, in my view, *excellent* news. Nobody expect viruses to remain stagnant & this one clearly not. So the booster prep is excellent news since we already *knew* this one is showing adaptive evolution!)

      1 reply 0 retweets 4 likes
    9. Josh Nathan-Kazis‏Verified account @joshnathankazis 26 Jan 2021
      Replying to @zeynep @lisang @BiellaColeman

      I suppose. But I don't think we should understate the news, which is that, a) Moderna will now try a third dose six to 12 months after the first, to protect against emerging strains, and b) they'll also test a new booster specific to the S.A. strain.

      1 reply 0 retweets 2 likes
    10. Josh Nathan-Kazis‏Verified account @joshnathankazis 26 Jan 2021
      Replying to @joshnathankazis @zeynep and

      Which is good! But they're doing it because of something they're already seeing begin to happen in the lab. And it was that - the sixfold reduction in neutralizing titers - that seemed like not great news, to me.

      2 replies 0 retweets 1 like
      zeynep tufekci‏Verified account @zeynep 26 Jan 2021
      Replying to @joshnathankazis @lisang @BiellaColeman

      OK. It’s actually great news. That sixfold reduction does not *at all* correspond to a drop in vaccine efficacy. Vaccines aren’t drugs. To simplify, the news was that the vaccine clearing a bar comfortably! I realize it sounds confusing. That’s why I responded.

      6:11 PM - 26 Jan 2021
      • 5 Likes
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      1 reply 0 retweets 5 likes
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 26 Jan 2021
          Replying to @zeynep @joshnathankazis and

          Similarly, given that we already know adaptive evolution is happening, I found the preparation for a booster to be really positive too. It would be bad news if they weren’t—but it is abundance of caution. We’re still looking great with the existing vaccines—just we need more now.

          1 reply 0 retweets 3 likes
        3. Josh Nathan-Kazis‏Verified account @joshnathankazis 26 Jan 2021
          Replying to @zeynep @lisang @BiellaColeman

          Yeah, I understand that they still expect the vaccine to work as well. But I also understand, from other reporting, that as recently as two weeks ago, the need to develop strain-specific boosters felt much farther off. Anyway, appreciate the response.

          0 replies 0 retweets 2 likes
        4. End of conversation

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