Also, to be clear: our own op-ed advocated for immediate single-dose trials and resources/funding for it. A lot has happened since then, and many countries are forging ahead, it seems, with at least spacing boosters. That part is not mine to comment except: PLEASE COLLECT DATA.
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The man who leads the UK RECOVERY trials which produced incredibly useful information—including drugs that greatly reduce mortality—suggests a randomized trial of delayed dosing. Amazing how “controversies” evolve.
(Yes, we obviously should, as per first tweet in this thread.)https://twitter.com/MartinLandray/status/1353272270270181379 …Show this thread -
Seems Michael Osterholm (of Biden Covid task force) calls for delaying the second dose a few months to increase coverage now. (Because I keep having to clarify: My co-authored piece called for *A TRIAL* exactly so such discussions could have better data). https://www.cidrap.umn.edu/covid-19/podcasts-webinars/episode-42 …pic.twitter.com/f1AkWZjIrv
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Updating this thread started on December 18, 2020 with me and
@michaelmina_lab proposing an immediate *trial* for delaying the booster and monitoring the results. We both caught much grief then but if we had started a trial then, we'd know for sure by now.https://twitter.com/Atul_Gawande/status/1377275975050924040 …Show this thread
End of conversation
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Agree with your plea.
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Agreed. It seems very irresponsible to simply make up timelines when no one has tested any of this. I don’t think anyone who got the first shot thought they were automatically enrolling in a clinical trial.
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Hard agree. Doing more research is not counter to doing guesswork in a crisis, it makes the guesses more likely to land on the right answers (or closer). We will never know everything we need to, but the 2nd dose question is amenable to study and abs pivotal right now.
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