One reaction I see is a lot of wagon-circling and how-dare-you indignation. I wouldn't even mind it for some topics if it had a chance of working! It's the 21st century! It has no chance of working! Have to be out there engaging the ideas—if they think it's good/bad/terrible+how.
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Biden administration will indeed stop keeping second dose in reserve and front-load the vaccine distribution. (NB: I advocated for a *trial* asap on delayed booster & not keeping second dose in reserve. I also support having these trades-off discussions).https://www.cnn.com/2021/01/08/politics/biden-vaccine-strategy/index.html …
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So update. CDC says some delay is okay & "if the second dose is administered beyond these intervals, there is no need to restart the series." I will repeat my plea that such modifications need a randomization and data gathering component for more clarity.https://twitter.com/MikeNedelman/status/1352406577664450561 …
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The man who leads the UK RECOVERY trials which produced incredibly useful information—including drugs that greatly reduce mortality—suggests a randomized trial of delayed dosing. Amazing how “controversies” evolve.
(Yes, we obviously should, as per first tweet in this thread.)https://twitter.com/MartinLandray/status/1353272270270181379 …Show this thread -
Seems Michael Osterholm (of Biden Covid task force) calls for delaying the second dose a few months to increase coverage now. (Because I keep having to clarify: My co-authored piece called for *A TRIAL* exactly so such discussions could have better data). https://www.cidrap.umn.edu/covid-19/podcasts-webinars/episode-42 …pic.twitter.com/f1AkWZjIrv
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Updating this thread started on December 18, 2020 with me and
@michaelmina_lab proposing an immediate *trial* for delaying the booster and monitoring the results. We both caught much grief then but if we had started a trial then, we'd know for sure by now.https://twitter.com/Atul_Gawande/status/1377275975050924040 …Show this thread
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Of course the
@RepKevinBrady post-single-shot COVID infection is a clear example of the potential risk (though we don't have info on viral load)https://www.npr.org/sections/coronavirus-live-updates/2021/01/06/953839030/top-house-republican-to-quarantine-after-testing-positive-for-coronavirus … -
Risk of what? There will be some breakthrough cases even after the booster. If you mean getting the booster is better, yes, of course! That was never the question. If there were no supply issues this wouldn’t be an issue at all.
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Protections do not kick in for about two weeks.
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I agree with testing first but what do you think about the risk of mutation?https://twitter.com/EJohnWherry/status/1346130823213408256 …
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Speculative and low likelihood of escape mutations. Here's 4 reasons why:https://twitter.com/CADoctorJ1/status/1347239061476425728?s=20 …
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