Two more (pretty senior) scholars (one is a former associate director of NIH) are advocating for modifying vaccine roll-out—they suggest delaying second dose. Less Twitter dunking, more constructive effort to figure out how to test this would be excellent.https://www.medpagetoday.com/infectiousdisease/covid19/90358 …
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WHO expert committee says delaying booster up to six weeks (given supply issues) rather than three is okay (based on existing data) and also says will update recommendations for delay as more data becomes available.https://twitter.com/BogochIsaac/status/1347545566679592960 …
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Details from the WHO expert committee: "Countries experiencing exceptional epidemiological circumstances may consider delaying for a short period the administration of the second dose as a pragmatic approach to maximizing the number of individuals benefiting from a first dose."pic.twitter.com/INAZ6Iy6j5
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Biden administration will indeed stop keeping second dose in reserve and front-load the vaccine distribution. (NB: I advocated for a *trial* asap on delayed booster & not keeping second dose in reserve. I also support having these trades-off discussions).https://www.cnn.com/2021/01/08/politics/biden-vaccine-strategy/index.html …
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So update. CDC says some delay is okay & "if the second dose is administered beyond these intervals, there is no need to restart the series." I will repeat my plea that such modifications need a randomization and data gathering component for more clarity.https://twitter.com/MikeNedelman/status/1352406577664450561 …
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The man who leads the UK RECOVERY trials which produced incredibly useful information—including drugs that greatly reduce mortality—suggests a randomized trial of delayed dosing. Amazing how “controversies” evolve.
(Yes, we obviously should, as per first tweet in this thread.)https://twitter.com/MartinLandray/status/1353272270270181379 …Show this thread -
Seems Michael Osterholm (of Biden Covid task force) calls for delaying the second dose a few months to increase coverage now. (Because I keep having to clarify: My co-authored piece called for *A TRIAL* exactly so such discussions could have better data). https://www.cidrap.umn.edu/covid-19/podcasts-webinars/episode-42 …pic.twitter.com/f1AkWZjIrv
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Updating this thread started on December 18, 2020 with me and
@michaelmina_lab proposing an immediate *trial* for delaying the booster and monitoring the results. We both caught much grief then but if we had started a trial then, we'd know for sure by now.https://twitter.com/Atul_Gawande/status/1377275975050924040 …Show this thread
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What's your take on concerns that a delayed second dose could increase risks of resistant strains appearing? I've seen several people voicing that concern, but I haven't found any specific models for it or attempts to weigh the tradeoff.
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