1) If we want to generate difficult viral escape mutants in the lab (e.g. for epitope mapping), we subject the virus to low antibody pressure and then slowly move up. A little bit like after one vaccine dose. I think it would be good to give the second dose as soon as possible.
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What that entire thread — with many outstanding scientists — says is, "we don't know."
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With some of them coming strongly on the side of delaying the booster, some not. On repeat: you should ask people like Klugman or Iwasaki (actual experts) among many, not me! I can only say that there are trade-offs on all sides, a sucky situation & credentials on both sides.
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