1) If we want to generate difficult viral escape mutants in the lab (e.g. for epitope mapping), we subject the virus to low antibody pressure and then slowly move up. A little bit like after one vaccine dose. I think it would be good to give the second dose as soon as possible.
-
Show this thread
-
-
Replying to @Merz @florian_krammer
Great to hear Florian thinks 12 weeks isn't a big problem—which I heard from many in the field which, as I said, I am not in a position to judge but the number of experts saying that is reassuring. I think everyone agrees boosters as soon as possible is a good idea.
11 replies 4 retweets 63 likes -
zeynep tufekci Retweeted Keith Klugman
Did you see tweets of Keith Klugman of Gates? https://twitter.com/findingpneumo/status/1344268340857081858 … I had forgotten to flag them or you (you had mentioned being interested in Gates Foundation approach).
zeynep tufekci added,
Keith Klugman @findingpneumoWay to go UK vaccine advisory committee - 1st doses protect more people using the three EUA vaccines in US or UK than do 2nd doses - limited supply in US allows excess deaths by restricting first doses of covid vaccines - 2nd doses are still valuable but can and should be delayed https://twitter.com/PeterHorby/status/1344190491781443585 …2 replies 0 retweets 7 likes -
zeynep tufekci Retweeted Keith Klugman
zeynep tufekci added,
2 replies 0 retweets 3 likes -
Replying to @zeynep @florian_krammer
I did. I think he’s overly optimistic, and that you are as well.
2 replies 0 retweets 5 likes -
Alex Merz Retweeted Eric Topol
Alex Merz added,
Eric TopolVerified account @EricTopolHow to accelerate#SARSCoV2 evolution, a fairly slowly evolving virus, for the potential of functional mutations 1. Infection of immunocompromised hosts 2. Give convalescent plasma (without evidence) to hundreds of thousands of people w/ covid 3. Use ? effective vaccine regimens pic.twitter.com/o5N8K6gobcShow this thread1 reply 0 retweets 8 likes
Yes, I know! Again, I'm not the expert! As Eric himself says, there are lots of people of excellent credentials and with deep expertise (like Klugman or Iwasaki or Wachter and Jha and UK JVIC to name just a few, among many) on the other side of debate.
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.